SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function

SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function

Abstract Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co‐agonist activity for NMDA receptors (NMDARs), have been considered to be important targets for the treatment of brain disorders with suppressed NMDAR function such as schizop...

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Main Authors: Mihyun Bae, Junyeop Daniel Roh, Youjoung Kim, Seong Soon Kim, Hye Min Han, Esther Yang, Hyojin Kang, Suho Lee, Jin Yong Kim, Ryeonghwa Kang, Hwajin Jung, Taesun Yoo, Hyosang Kim, Doyoun Kim, Heejeong Oh, Sungwook Han, Dayeon Kim, Jinju Han, Yong Chul Bae, Hyun Kim, Sunjoo Ahn, Andrew M Chan, Daeyoup Lee, Jin Woo Kim, Eunjoon Kim
Format: Article
Language:English
Published: Springer Nature 2021-01-01
Series:EMBO Molecular Medicine
Subjects:
glycine transporter
neuropsychiatric disorders
NMDA receptor
PTEN
Slc6a20
Online Access:https://doi.org/10.15252/emmm.202012632
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