Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano Compounds
A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction of <i>α</i>-hydroxy ketones and cyano compounds. The reaction proceeds under relatively mild conditions, utilizes readily available starting materia...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/30/8/1832 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850143933493936128 |
|---|---|
| author | Yu Zeng Shi-Hang Yang Ji-Lin Guo Yun Li Ting Lin Zhao-Yang Wang |
| author_facet | Yu Zeng Shi-Hang Yang Ji-Lin Guo Yun Li Ting Lin Zhao-Yang Wang |
| author_sort | Yu Zeng |
| collection | DOAJ |
| description | A novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction of <i>α</i>-hydroxy ketones and cyano compounds. The reaction proceeds under relatively mild conditions, utilizes readily available starting materials, and exhibits good functional group tolerance and high yields. Notably, this reaction obviates the need for expensive metal catalysts and introduces crucial functional groups such as amino and cyano moieties. Furthermore, it avoids the prerequisite functionalization of substrates, thereby enhancing atomic economy. |
| format | Article |
| id | doaj-art-e7bc513ab6ac447e95f1b93cdfa5a6ca |
| institution | OA Journals |
| issn | 1420-3049 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj-art-e7bc513ab6ac447e95f1b93cdfa5a6ca2025-08-20T02:28:32ZengMDPI AGMolecules1420-30492025-04-01308183210.3390/molecules30081832Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano CompoundsYu Zeng0Shi-Hang Yang1Ji-Lin Guo2Yun Li3Ting Lin4Zhao-Yang Wang5School of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, ChinaSchool of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, ChinaSchool of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, ChinaSchool of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, ChinaSchool of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, ChinaSchool of Chemistry, South China Normal University, Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine, GDMPA Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals, Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, Guangzhou 510006, ChinaA novel method for the efficient and straightforward synthesis of tetrasubstituted furans is presented, employing a base-catalyzed reaction of <i>α</i>-hydroxy ketones and cyano compounds. The reaction proceeds under relatively mild conditions, utilizes readily available starting materials, and exhibits good functional group tolerance and high yields. Notably, this reaction obviates the need for expensive metal catalysts and introduces crucial functional groups such as amino and cyano moieties. Furthermore, it avoids the prerequisite functionalization of substrates, thereby enhancing atomic economy.https://www.mdpi.com/1420-3049/30/8/1832<i>α</i>-hydroxy ketonescyano compoundstetrasubstituted furansgreen synthesismetal-free catalysis |
| spellingShingle | Yu Zeng Shi-Hang Yang Ji-Lin Guo Yun Li Ting Lin Zhao-Yang Wang Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano Compounds Molecules <i>α</i>-hydroxy ketones cyano compounds tetrasubstituted furans green synthesis metal-free catalysis |
| title | Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano Compounds |
| title_full | Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano Compounds |
| title_fullStr | Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano Compounds |
| title_full_unstemmed | Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano Compounds |
| title_short | Metal-Free Catalytic Synthesis of Tetrasubstituted Furans from <i>α</i>-Hydroxy Ketones and Cyano Compounds |
| title_sort | metal free catalytic synthesis of tetrasubstituted furans from i α i hydroxy ketones and cyano compounds |
| topic | <i>α</i>-hydroxy ketones cyano compounds tetrasubstituted furans green synthesis metal-free catalysis |
| url | https://www.mdpi.com/1420-3049/30/8/1832 |
| work_keys_str_mv | AT yuzeng metalfreecatalyticsynthesisoftetrasubstitutedfuransfromiaihydroxyketonesandcyanocompounds AT shihangyang metalfreecatalyticsynthesisoftetrasubstitutedfuransfromiaihydroxyketonesandcyanocompounds AT jilinguo metalfreecatalyticsynthesisoftetrasubstitutedfuransfromiaihydroxyketonesandcyanocompounds AT yunli metalfreecatalyticsynthesisoftetrasubstitutedfuransfromiaihydroxyketonesandcyanocompounds AT tinglin metalfreecatalyticsynthesisoftetrasubstitutedfuransfromiaihydroxyketonesandcyanocompounds AT zhaoyangwang metalfreecatalyticsynthesisoftetrasubstitutedfuransfromiaihydroxyketonesandcyanocompounds |