Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

Molecular basis underpinning MR1 allomorph recognition by an MR1-restricted T cell receptor

IntroductionThe MHC-class-I-related molecule MR1 presents small metabolites of microbial and self-origin to T cells bearing semi-invariant or variant T cell receptors. One such T cell receptor, MC.7.G5, was previously shown to confer broad MR1-restricted reactivity to tumor cells but not normal cell...

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Bibliographic Details
Main Authors: Richard J. Suckling, Cevriye Pamukcu, Robert Alan Simmons, Daniel Fonseca, Emma Grant, Rory Harrison, Saher A. Shaikh, Rahul C. Khanolkar, Hemza Ghadbane, Andrew Creese, Miriam Hock, Thomas G. Gligoris, Marco Lepore, Vijaykumar Karuppiah, Mariolina Salio
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
MR1
cancer
metabolites
MAIT
TCR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1547664/full
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