COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITIS
Aim of this study was to investigate of NAD(P)-dependent dehydrogenases activity in lymphocytes at different outcomes widespread purulent peritonitis(WPP). Enzyme activity in blood lymphocytes was determined by bioluminescent method. Found that patients with a poor outcome of WPP in blood lymphocyte...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2014-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/225 |
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| author | A. A. Savchenko D. E. Zdzitovetsky N. A. Luzan |
| author_facet | A. A. Savchenko D. E. Zdzitovetsky N. A. Luzan |
| author_sort | A. A. Savchenko |
| collection | DOAJ |
| description | Aim of this study was to investigate of NAD(P)-dependent dehydrogenases activity in lymphocytes at different outcomes widespread purulent peritonitis(WPP). Enzyme activity in blood lymphocytes was determined by bioluminescent method. Found that patients with a poor outcome of WPP in blood lymphocytes made more pronounced reaction of lipid anabolism and catabolism of xenobiotics. Regardless of the outcome of the disease in blood lymphocytes of WPP patients reduced levels of enzymes activity that determine the intensity of anaerobic and aerobic respiration and the level of plastic processes, but the activation reactions of lipid catabolism and transport products through glycerol-3-phosphate dehydrogenase on reactions of glycolysis. Based on the informativeness of the NAD(P)-dependent dehydrogenases activity in the classification neural network model for the disease outcome, metabolic coefficient is proposed, which has prognostic significance. |
| format | Article |
| id | doaj-art-e7b3d37a3d464e7a85e3071c684b227e |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-e7b3d37a3d464e7a85e3071c684b227e2025-08-20T03:21:42ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-10-01135798610.20538/1682-0363-2014-5-79-86223COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITISA. A. Savchenko0D. E. Zdzitovetsky1N. A. Luzan2Institute o f Medical Problems o f the North, KrasnoyarsKrasnoyarsk State Medical University named after Prof. V.F. Voyno-Yasenetsky, KrasnoyarskInstitute o f Medical Problems o f the North, KrasnoyarsAim of this study was to investigate of NAD(P)-dependent dehydrogenases activity in lymphocytes at different outcomes widespread purulent peritonitis(WPP). Enzyme activity in blood lymphocytes was determined by bioluminescent method. Found that patients with a poor outcome of WPP in blood lymphocytes made more pronounced reaction of lipid anabolism and catabolism of xenobiotics. Regardless of the outcome of the disease in blood lymphocytes of WPP patients reduced levels of enzymes activity that determine the intensity of anaerobic and aerobic respiration and the level of plastic processes, but the activation reactions of lipid catabolism and transport products through glycerol-3-phosphate dehydrogenase on reactions of glycolysis. Based on the informativeness of the NAD(P)-dependent dehydrogenases activity in the classification neural network model for the disease outcome, metabolic coefficient is proposed, which has prognostic significance.https://bulletin.ssmu.ru/jour/article/view/225widespread purulent peritonitisdisease outcomenad-dependent dehydrogenasesnadp-dependent dehydrogenaseslymphocytesmetabolism. |
| spellingShingle | A. A. Savchenko D. E. Zdzitovetsky N. A. Luzan COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITIS Бюллетень сибирской медицины widespread purulent peritonitis disease outcome nad-dependent dehydrogenases nadp-dependent dehydrogenases lymphocytes metabolism. |
| title | COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITIS |
| title_full | COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITIS |
| title_fullStr | COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITIS |
| title_full_unstemmed | COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITIS |
| title_short | COMMUNICATION OF NAD- AND NADP-DEPENDENT DEHYDROGENASE ACTIVITIES IN LYMPHOCYTES WITH OUTCOME OF PREVALENCE PURULENT PERITONITIS |
| title_sort | communication of nad and nadp dependent dehydrogenase activities in lymphocytes with outcome of prevalence purulent peritonitis |
| topic | widespread purulent peritonitis disease outcome nad-dependent dehydrogenases nadp-dependent dehydrogenases lymphocytes metabolism. |
| url | https://bulletin.ssmu.ru/jour/article/view/225 |
| work_keys_str_mv | AT aasavchenko communicationofnadandnadpdependentdehydrogenaseactivitiesinlymphocyteswithoutcomeofprevalencepurulentperitonitis AT dezdzitovetsky communicationofnadandnadpdependentdehydrogenaseactivitiesinlymphocyteswithoutcomeofprevalencepurulentperitonitis AT naluzan communicationofnadandnadpdependentdehydrogenaseactivitiesinlymphocyteswithoutcomeofprevalencepurulentperitonitis |