Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints

Assessing the potential causal effects of 1099 plasma metabolites on 2099 binary disease endpoints

Abstract Metabolites are small molecules that are useful for estimating disease risk and elucidating disease biology. Here, we perform two-sample Mendelian randomization to systematically infer the potential causal effects of 1099 plasma metabolites measured in 6136 Finnish men from the METSIM study...

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Main Authors: Xianyong Yin, Jack Li, Debraj Bose, Jeffrey Okamoto, Annie Kwon, Anne U. Jackson, Lilian Fernandes Silva, Anniina Oravilahti, Xiaomeng Chu, Heather M. Stringham, Lei Liu, Ruyi Peng, Zhijie Xia, Samuli Ripatti, Mark Daly, Aarno Palotie, Laura J. Scott, Charles F. Burant, Eric B. Fauman, Xiaoquan Wen, Michael Boehnke, Markku Laakso, Jean Morrison
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58129-2
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