Mechanisms of the cytotoxicity of carbon nanotubes
Probable mechanisms of cytotoxicity of a total fraction of multi-walled carbon nanotubes using spin probe methods (in human erythrocytes and rat hepatocytes) and electrical breakdown (in mouse oocytes) have been studied. Erythrocyte membrane damage induced by carbon nanotubes is developed in time. A...
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| Format: | Article |
| Language: | English |
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Chuiko Institute of Surface Chemistry of NAS of Ukraine
2011-05-01
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| Series: | Хімія, фізика та технологія поверхні |
| Online Access: | https://cpts.com.ua/index.php/cpts/article/view/88 |
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| author | M. T. Kartel V. P. Chernykh L. V. Ivanov E. A. Gordienko S. N. Kovalenko Yu. I. Gubin O. A. Nardid E. I. Smolyaninova |
| author_facet | M. T. Kartel V. P. Chernykh L. V. Ivanov E. A. Gordienko S. N. Kovalenko Yu. I. Gubin O. A. Nardid E. I. Smolyaninova |
| author_sort | M. T. Kartel |
| collection | DOAJ |
| description | Probable mechanisms of cytotoxicity of a total fraction of multi-walled carbon nanotubes using spin probe methods (in human erythrocytes and rat hepatocytes) and electrical breakdown (in mouse oocytes) have been studied. Erythrocyte membrane damage induced by carbon nanotubes is developed in time. After two-day exposure at 279 K the erythrocyte samples with carbon nanotubes concentrations of 10, 50, 100, and 200 ?g / ml showed a part of damaged erythrocytes of 4, 10, 16, and 25%, respectively. A 4 h exposure of rat liver homogenate with carbon nanotubes at 273 K resulted in a significant decrease in liver homogenate mitochondrial activity. The study of the processes of oocyte electroporation has shown that probable mechanisms of nanotube cytotoxicity are associated with an increase in membrane conductivity, alteration of surface potential, formation of defects within the membrane, and as a consequence, with an increase in membrane permeability. In addition to their capability to affect membrane structural changes, the nanotubes have a capacity to inhibit delicate electrochemical processes in cells. |
| format | Article |
| id | doaj-art-e7ad54a13d494315a0d2a3d3fae0bd80 |
| institution | Kabale University |
| issn | 2079-1704 2518-1238 |
| language | English |
| publishDate | 2011-05-01 |
| publisher | Chuiko Institute of Surface Chemistry of NAS of Ukraine |
| record_format | Article |
| series | Хімія, фізика та технологія поверхні |
| spelling | doaj-art-e7ad54a13d494315a0d2a3d3fae0bd802025-08-20T03:31:14ZengChuiko Institute of Surface Chemistry of NAS of UkraineХімія, фізика та технологія поверхні2079-17042518-12382011-05-0122Mechanisms of the cytotoxicity of carbon nanotubesM. T. Kartel0V. P. Chernykh1L. V. Ivanov2E. A. Gordienko3S. N. Kovalenko4Yu. I. Gubin5O. A. Nardid6E. I. Smolyaninova7Chuiko Institute of Surface Chemistry of National Academy of Sciences of UkraineNational University of Pharmacy, the Ministry of Heals of UkraineNational University of Pharmacy, the Ministry of Heals of UkraineInstitute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of UkraineNational University of Pharmacy, the Ministry of Heals of UkraineNational University of Pharmacy, the Ministry of Heals of UkraineInstitute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of UkraineInstitute for Problems of Cryobiology and Cryomedicine of National Academy of Sciences of UkraineProbable mechanisms of cytotoxicity of a total fraction of multi-walled carbon nanotubes using spin probe methods (in human erythrocytes and rat hepatocytes) and electrical breakdown (in mouse oocytes) have been studied. Erythrocyte membrane damage induced by carbon nanotubes is developed in time. After two-day exposure at 279 K the erythrocyte samples with carbon nanotubes concentrations of 10, 50, 100, and 200 ?g / ml showed a part of damaged erythrocytes of 4, 10, 16, and 25%, respectively. A 4 h exposure of rat liver homogenate with carbon nanotubes at 273 K resulted in a significant decrease in liver homogenate mitochondrial activity. The study of the processes of oocyte electroporation has shown that probable mechanisms of nanotube cytotoxicity are associated with an increase in membrane conductivity, alteration of surface potential, formation of defects within the membrane, and as a consequence, with an increase in membrane permeability. In addition to their capability to affect membrane structural changes, the nanotubes have a capacity to inhibit delicate electrochemical processes in cells.https://cpts.com.ua/index.php/cpts/article/view/88 |
| spellingShingle | M. T. Kartel V. P. Chernykh L. V. Ivanov E. A. Gordienko S. N. Kovalenko Yu. I. Gubin O. A. Nardid E. I. Smolyaninova Mechanisms of the cytotoxicity of carbon nanotubes Хімія, фізика та технологія поверхні |
| title | Mechanisms of the cytotoxicity of carbon nanotubes |
| title_full | Mechanisms of the cytotoxicity of carbon nanotubes |
| title_fullStr | Mechanisms of the cytotoxicity of carbon nanotubes |
| title_full_unstemmed | Mechanisms of the cytotoxicity of carbon nanotubes |
| title_short | Mechanisms of the cytotoxicity of carbon nanotubes |
| title_sort | mechanisms of the cytotoxicity of carbon nanotubes |
| url | https://cpts.com.ua/index.php/cpts/article/view/88 |
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