Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis

Neoadjuvant immunotherapy for DNA mismatch repair proficient/microsatellite stable non-metastatic rectal cancer: a systematic review and meta-analysis

BackgroundNeoadjuvant immunotherapy (NIT) has been endorsed by clinical guidelines for the management of DNA mismatch repair deficiency/microsatellite instability-high (dMMR/MSI-H) locally advanced rectal cancer (LARC). Nonetheless, the therapeutic efficacy of NIT in mismatch repair-proficient/micro...

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Bibliographic Details
Main Authors: Huan Zhang, Jing Huang, Huanji Xu, Nanhao Yin, Liyan Zhou, Jianxin Xue, Min Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
neoadjuvant immunotherapy
non-metastatic rectal cancer
mismatch repair-proficient/microsatellite stable
meta-analysis
efficacy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523455/full
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