The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces

The unique structure of the highly conserved PPLP region in HIV-1 Vif is critical for the formation of APOBEC3 recognition interfaces

ABSTRACT The human cellular cytidine deaminases APOBEC3s (A3s) inhibit virion infectivity factor (Vif)-deficient HIV-1 replication. However, virus-encoded Vifs abolish this defense system by specifically recruiting A3s to an E3 ubiquitin ligase complex to induce their degradation. The highly conserv...

Full description

Saved in:
Bibliographic Details
Main Authors: Yasumasa Iwatani, Kazuhiro Matsuoka, Hirotaka Ode, Mai Kubota, Yoshihiro Nakata, Yuka Setoyama, Kanako Kojima, Mayumi Imahashi, Yoshiyuki Yokomaku
Format: Article
Language:English
Published: American Society for Microbiology 2025-03-01
Series:mBio
Subjects:
APOBEC3
HIV-1
Vif
PPLP
ubiquitination
antiviral factor
Online Access:https://journals.asm.org/doi/10.1128/mbio.03332-24
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items