Role of miRNA in adult ocular tumorigenesis
In recent years, cancer research has made huge advances also thanks to the discovery of the role of non-coding RNAs in the control of tumorigenesis, tumor proliferation, migration and metastasis and therefore also in the diagnosis and therapy of tumors. This work aims to review the most recent liter...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Molecular Biosciences |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1459761/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850186795989336064 |
|---|---|
| author | Arianna Romani Arianna Romani Elisabetta Melloni Elisabetta Melloni Giada Lodi Giada Lodi Francesca Bompan Rebecca Foschi Rebecca Foschi Enrico Zauli Elena Pozza Paola Secchiero Paola Secchiero Giorgio Zauli Maurizio Previati Rebecca Voltan Rebecca Voltan |
| author_facet | Arianna Romani Arianna Romani Elisabetta Melloni Elisabetta Melloni Giada Lodi Giada Lodi Francesca Bompan Rebecca Foschi Rebecca Foschi Enrico Zauli Elena Pozza Paola Secchiero Paola Secchiero Giorgio Zauli Maurizio Previati Rebecca Voltan Rebecca Voltan |
| author_sort | Arianna Romani |
| collection | DOAJ |
| description | In recent years, cancer research has made huge advances also thanks to the discovery of the role of non-coding RNAs in the control of tumorigenesis, tumor proliferation, migration and metastasis and therefore also in the diagnosis and therapy of tumors. This work aims to review the most recent literature involving the study of miRNAs in ocular tumors affecting adult patients. We will introduce the role of miRNAs in tumorigenesis, and we will focus on summarizing the studies on uveal intraocular melanomas in which a role of microRNAs has been demonstrated. Similarly, we will also cover observations on miRNAs and eyelid cancers, especially sebaceous gland carcinoma, and cancers of the conjunctiva and the retina, excluding retinoblastoma which is typically a pediatric-onset tumor. We will summarize specific miRNAs that could be considered as diagnostic molecules or as therapeutic targets against some ocular cancer diseases, indicating their potentialities and limitations, considering also their administration as nanomedicine for the eye. |
| format | Article |
| id | doaj-art-e79b69e83f6d411d84056880fead1869 |
| institution | OA Journals |
| issn | 2296-889X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj-art-e79b69e83f6d411d84056880fead18692025-08-20T02:16:15ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2025-05-011210.3389/fmolb.2025.14597611459761Role of miRNA in adult ocular tumorigenesisArianna Romani0Arianna Romani1Elisabetta Melloni2Elisabetta Melloni3Giada Lodi4Giada Lodi5Francesca Bompan6Rebecca Foschi7Rebecca Foschi8Enrico Zauli9Elena Pozza10Paola Secchiero11Paola Secchiero12Giorgio Zauli13Maurizio Previati14Rebecca Voltan15Rebecca Voltan16Department of Translational Medicine, University of Ferrara, Ferrara, ItalyLTTA Centre, University of Ferrara, Ferrara, ItalyDepartment of Translational Medicine, University of Ferrara, Ferrara, ItalyLTTA Centre, University of Ferrara, Ferrara, ItalyLTTA Centre, University of Ferrara, Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, Ferrara, ItalyLTTA Centre, University of Ferrara, Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, Ferrara, ItalyDepartment of Translational Medicine, University of Ferrara, Ferrara, ItalyDepartment of Translational Medicine, University of Ferrara, Ferrara, ItalyDepartment of Translational Medicine, University of Ferrara, Ferrara, ItalyLTTA Centre, University of Ferrara, Ferrara, ItalyResearch Department, King Khaled Eye Specialistic Hospital, Riyadh, Saudi ArabiaDepartment of Translational Medicine, University of Ferrara, Ferrara, ItalyLTTA Centre, University of Ferrara, Ferrara, ItalyDepartment of Environmental and Prevention Sciences, University of Ferrara, Ferrara, ItalyIn recent years, cancer research has made huge advances also thanks to the discovery of the role of non-coding RNAs in the control of tumorigenesis, tumor proliferation, migration and metastasis and therefore also in the diagnosis and therapy of tumors. This work aims to review the most recent literature involving the study of miRNAs in ocular tumors affecting adult patients. We will introduce the role of miRNAs in tumorigenesis, and we will focus on summarizing the studies on uveal intraocular melanomas in which a role of microRNAs has been demonstrated. Similarly, we will also cover observations on miRNAs and eyelid cancers, especially sebaceous gland carcinoma, and cancers of the conjunctiva and the retina, excluding retinoblastoma which is typically a pediatric-onset tumor. We will summarize specific miRNAs that could be considered as diagnostic molecules or as therapeutic targets against some ocular cancer diseases, indicating their potentialities and limitations, considering also their administration as nanomedicine for the eye.https://www.frontiersin.org/articles/10.3389/fmolb.2025.1459761/fullmiRNAocular tumorsuveal melanomaeyeretinal cancereyelid cancer |
| spellingShingle | Arianna Romani Arianna Romani Elisabetta Melloni Elisabetta Melloni Giada Lodi Giada Lodi Francesca Bompan Rebecca Foschi Rebecca Foschi Enrico Zauli Elena Pozza Paola Secchiero Paola Secchiero Giorgio Zauli Maurizio Previati Rebecca Voltan Rebecca Voltan Role of miRNA in adult ocular tumorigenesis Frontiers in Molecular Biosciences miRNA ocular tumors uveal melanoma eye retinal cancer eyelid cancer |
| title | Role of miRNA in adult ocular tumorigenesis |
| title_full | Role of miRNA in adult ocular tumorigenesis |
| title_fullStr | Role of miRNA in adult ocular tumorigenesis |
| title_full_unstemmed | Role of miRNA in adult ocular tumorigenesis |
| title_short | Role of miRNA in adult ocular tumorigenesis |
| title_sort | role of mirna in adult ocular tumorigenesis |
| topic | miRNA ocular tumors uveal melanoma eye retinal cancer eyelid cancer |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2025.1459761/full |
| work_keys_str_mv | AT ariannaromani roleofmirnainadultoculartumorigenesis AT ariannaromani roleofmirnainadultoculartumorigenesis AT elisabettamelloni roleofmirnainadultoculartumorigenesis AT elisabettamelloni roleofmirnainadultoculartumorigenesis AT giadalodi roleofmirnainadultoculartumorigenesis AT giadalodi roleofmirnainadultoculartumorigenesis AT francescabompan roleofmirnainadultoculartumorigenesis AT rebeccafoschi roleofmirnainadultoculartumorigenesis AT rebeccafoschi roleofmirnainadultoculartumorigenesis AT enricozauli roleofmirnainadultoculartumorigenesis AT elenapozza roleofmirnainadultoculartumorigenesis AT paolasecchiero roleofmirnainadultoculartumorigenesis AT paolasecchiero roleofmirnainadultoculartumorigenesis AT giorgiozauli roleofmirnainadultoculartumorigenesis AT mauriziopreviati roleofmirnainadultoculartumorigenesis AT rebeccavoltan roleofmirnainadultoculartumorigenesis AT rebeccavoltan roleofmirnainadultoculartumorigenesis |