Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease
Although hepatic dysfunction is common in adult-onset Still's disease (AOSD), sometimes it is difficult to differentiate hepatic dysfunction due to AOSD itself from drug-induced hepatic dysfunction. Further, myalgia often occurs in patients with AOSD; however, AOSD patients complicated with myo...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/504897 |
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| author | Hidekatsu Yanai Nobuyuki Furutani Hiroshi Yoshida Norio Tada |
| author_facet | Hidekatsu Yanai Nobuyuki Furutani Hiroshi Yoshida Norio Tada |
| author_sort | Hidekatsu Yanai |
| collection | DOAJ |
| description | Although hepatic dysfunction is common in adult-onset Still's disease (AOSD), sometimes it is difficult to differentiate hepatic dysfunction due to AOSD itself from drug-induced hepatic dysfunction. Further, myalgia often occurs in patients with AOSD; however, AOSD patients complicated with myositis are rare. We report a 43-year-old Japanese man with AOSD who developed myositis and hepatic dysfunction which were deteriorated by multiple nonsteroidal antiinflammatory drugs (NSAIDs) and were dramatically ameliorated by a low-dose steroid therapy. A skin biopsy of salmon pink rash which is characteristic for AOSD showed leukocytoclastic vasculitis, and the markers for vasculitis, plasma von Willebrand factor, and vascular endothelial growth factor levels were elevated in this patient, suggesting an association between AOSD and systemic vasculitis. |
| format | Article |
| id | doaj-art-e799fbe7b8e14728a980e3976fde2896 |
| institution | OA Journals |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-e799fbe7b8e14728a980e3976fde28962025-08-20T02:21:10ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/504897504897Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's DiseaseHidekatsu Yanai0Nobuyuki Furutani1Hiroshi Yoshida2Norio Tada3Division of General Medicine, Department of Internal Medicine, The Jikei University School of Medicine, 163-1, Kashiwashita, Kashiwa, Chiba 277-8567, JapanDivision of General Medicine, Department of Internal Medicine, The Jikei University School of Medicine, 163-1, Kashiwashita, Kashiwa, Chiba 277-8567, JapanDepartment of Laboratory Medicine, The Jikei University School of Medicine, 163-1, Kashiwashita, Kashiwa, Chiba 277-8567, JapanDivision of General Medicine, Department of Internal Medicine, The Jikei University School of Medicine, 163-1, Kashiwashita, Kashiwa, Chiba 277-8567, JapanAlthough hepatic dysfunction is common in adult-onset Still's disease (AOSD), sometimes it is difficult to differentiate hepatic dysfunction due to AOSD itself from drug-induced hepatic dysfunction. Further, myalgia often occurs in patients with AOSD; however, AOSD patients complicated with myositis are rare. We report a 43-year-old Japanese man with AOSD who developed myositis and hepatic dysfunction which were deteriorated by multiple nonsteroidal antiinflammatory drugs (NSAIDs) and were dramatically ameliorated by a low-dose steroid therapy. A skin biopsy of salmon pink rash which is characteristic for AOSD showed leukocytoclastic vasculitis, and the markers for vasculitis, plasma von Willebrand factor, and vascular endothelial growth factor levels were elevated in this patient, suggesting an association between AOSD and systemic vasculitis.http://dx.doi.org/10.1155/2009/504897 |
| spellingShingle | Hidekatsu Yanai Nobuyuki Furutani Hiroshi Yoshida Norio Tada Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease Case Reports in Medicine |
| title | Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease |
| title_full | Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease |
| title_fullStr | Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease |
| title_full_unstemmed | Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease |
| title_short | Myositis, Vasculitis, Hepatic Dysfunction in Adult-Onset Still's Disease |
| title_sort | myositis vasculitis hepatic dysfunction in adult onset still s disease |
| url | http://dx.doi.org/10.1155/2009/504897 |
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