Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's disease
Abstract Introduction The impact of Alzheimer's disease (AD) on cognitive decline differs by sex. Composite scores are useful as singular outcomes in clinical trials, yet to date these have not been developed to measure sex‐specific change. Method We derived optimal composites from component sc...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.trci.2019.07.003 |
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| author | Sarah J. Banks Benjamin Shifflett Jody‐Lynn Berg Erin Sundermann Guerry Peavy Mark W. Bondi Steven D. Edland Alzheimer's Disease Neuroimaging Initiative |
| author_facet | Sarah J. Banks Benjamin Shifflett Jody‐Lynn Berg Erin Sundermann Guerry Peavy Mark W. Bondi Steven D. Edland Alzheimer's Disease Neuroimaging Initiative |
| author_sort | Sarah J. Banks |
| collection | DOAJ |
| description | Abstract Introduction The impact of Alzheimer's disease (AD) on cognitive decline differs by sex. Composite scores are useful as singular outcomes in clinical trials, yet to date these have not been developed to measure sex‐specific change. Method We derived optimal composites from component scales available in the AD Neuroimaging Initiative (ADNI) database among cognitively normal and mild cognitively impaired subjects who are cerebrospinal fluid amyloid‐β positive for early AD. Maximally sensitive composites were constructed separately for men and women using standard formulas. We compared the statistical power of the composites with the ADNI Prodromal Alzheimer's Cognitive Composite. Results Among 9 cognitive measures and clinical dementia rating sum of boxes, the optimal sex‐specific composites included 5 measures, including the clinical dementia rating and 4 distinct cognitive measures. The sex‐specific composites consistently outperformed sex‐agnostic composites and the ADNI Prodromal Alzheimer's Cognitive Composite. Discussion Sex‐specific composite scales may improve the power of longitudinal studies of early AD and clinical trials. |
| format | Article |
| id | doaj-art-e798b0cb21784e4da8478873028f690c |
| institution | OA Journals |
| issn | 2352-8737 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj-art-e798b0cb21784e4da8478873028f690c2025-08-20T02:09:55ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372019-01-015150851410.1016/j.trci.2019.07.003Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's diseaseSarah J. Banks0Benjamin Shifflett1Jody‐Lynn Berg2Erin Sundermann3Guerry Peavy4Mark W. Bondi5Steven D. Edland6Alzheimer's Disease Neuroimaging InitiativeDepartment of NeurosciencesUniversity of CaliforniaSan DiegoLa JollaCAUSADepartment of Family Medicine and Public HealthUCSDLa JollaCADepartment of NeurosciencesUniversity of CaliforniaSan DiegoLa JollaCAUSADepartment of PsychiatryUniversity of CaliforniaSan DiegoLa JollaCAUSADepartment of NeurosciencesUniversity of CaliforniaSan DiegoLa JollaCAUSADepartment of PsychiatryUniversity of CaliforniaSan DiegoLa JollaCAUSADepartment of Family Medicine and Public HealthUCSDLa JollaCAAbstract Introduction The impact of Alzheimer's disease (AD) on cognitive decline differs by sex. Composite scores are useful as singular outcomes in clinical trials, yet to date these have not been developed to measure sex‐specific change. Method We derived optimal composites from component scales available in the AD Neuroimaging Initiative (ADNI) database among cognitively normal and mild cognitively impaired subjects who are cerebrospinal fluid amyloid‐β positive for early AD. Maximally sensitive composites were constructed separately for men and women using standard formulas. We compared the statistical power of the composites with the ADNI Prodromal Alzheimer's Cognitive Composite. Results Among 9 cognitive measures and clinical dementia rating sum of boxes, the optimal sex‐specific composites included 5 measures, including the clinical dementia rating and 4 distinct cognitive measures. The sex‐specific composites consistently outperformed sex‐agnostic composites and the ADNI Prodromal Alzheimer's Cognitive Composite. Discussion Sex‐specific composite scales may improve the power of longitudinal studies of early AD and clinical trials.https://doi.org/10.1016/j.trci.2019.07.003Sex differencesCognitionClinical trial outcomesAlzheimer's diseaseComposites |
| spellingShingle | Sarah J. Banks Benjamin Shifflett Jody‐Lynn Berg Erin Sundermann Guerry Peavy Mark W. Bondi Steven D. Edland Alzheimer's Disease Neuroimaging Initiative Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's disease Alzheimer’s & Dementia: Translational Research & Clinical Interventions Sex differences Cognition Clinical trial outcomes Alzheimer's disease Composites |
| title | Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's disease |
| title_full | Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's disease |
| title_fullStr | Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's disease |
| title_full_unstemmed | Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's disease |
| title_short | Sex‐specific composite scales for longitudinal studies of incipient Alzheimer's disease |
| title_sort | sex specific composite scales for longitudinal studies of incipient alzheimer s disease |
| topic | Sex differences Cognition Clinical trial outcomes Alzheimer's disease Composites |
| url | https://doi.org/10.1016/j.trci.2019.07.003 |
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