Noninvasive Techniques for Management of Erythema Multiforme

An 18-year-old man was referred for a diagnosis of extensive oral lesions. During the interview, he reported a medical history of ganglionic tuberculosis, type 2 herpes infection, and significant weight loss due to dysphagia. Intraoral exam revealed multiple painful and ulcerated lesions covered by...

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Main Authors: Fabiana Martins, Debora Pallos, Jodkandlys Candeia, Rodrigo Zerbinati, Paulo Henrique Braz-Silva, Luana Campos
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Case Reports in Dentistry
Online Access:http://dx.doi.org/10.1155/2023/9938939
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author Fabiana Martins
Debora Pallos
Jodkandlys Candeia
Rodrigo Zerbinati
Paulo Henrique Braz-Silva
Luana Campos
author_facet Fabiana Martins
Debora Pallos
Jodkandlys Candeia
Rodrigo Zerbinati
Paulo Henrique Braz-Silva
Luana Campos
author_sort Fabiana Martins
collection DOAJ
description An 18-year-old man was referred for a diagnosis of extensive oral lesions. During the interview, he reported a medical history of ganglionic tuberculosis, type 2 herpes infection, and significant weight loss due to dysphagia. Intraoral exam revealed multiple painful and ulcerated lesions covered by pseudomembrane. Lesions were observed on the labial and buccal mucosa, tongue, and soft palate. The laboratory findings included serum positivity for the Epstein-Barr virus, and salivary tests showed positive values for herpes simplex virus (HSV-2) and human herpesvirus (HHV-7). The diagnostic hypothesis was based on clinical findings and viral infection detected in the saliva, which triggered an immunological disorder, that is, erythema multiforme (EM). The treatment consisted of antimicrobial photodynamic therapy (aPDT), with substantial improvement in pain and healing as seen in the following twenty-four hours. Complete resolution of the lesions was achieved five days after the first session. Once the diagnosis of virus-induced EM was confirmed, noninvasive techniques (e.g., salivary tests and aPDT) were very successful and can be indicated for managing these lesions.
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publishDate 2023-01-01
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series Case Reports in Dentistry
spelling doaj-art-e797ee72ad1c40d6ac6bfd1e3e1245452025-02-03T06:42:55ZengWileyCase Reports in Dentistry2090-64552023-01-01202310.1155/2023/9938939Noninvasive Techniques for Management of Erythema MultiformeFabiana Martins0Debora Pallos1Jodkandlys Candeia2Rodrigo Zerbinati3Paulo Henrique Braz-Silva4Luana Campos5Postgraduate Program in DentistryPostgraduate Program in DentistryPostgraduate Program in DentistryLaboratory of Virology (LIM-52)Department of StomatologyPostgraduate Program in DentistryAn 18-year-old man was referred for a diagnosis of extensive oral lesions. During the interview, he reported a medical history of ganglionic tuberculosis, type 2 herpes infection, and significant weight loss due to dysphagia. Intraoral exam revealed multiple painful and ulcerated lesions covered by pseudomembrane. Lesions were observed on the labial and buccal mucosa, tongue, and soft palate. The laboratory findings included serum positivity for the Epstein-Barr virus, and salivary tests showed positive values for herpes simplex virus (HSV-2) and human herpesvirus (HHV-7). The diagnostic hypothesis was based on clinical findings and viral infection detected in the saliva, which triggered an immunological disorder, that is, erythema multiforme (EM). The treatment consisted of antimicrobial photodynamic therapy (aPDT), with substantial improvement in pain and healing as seen in the following twenty-four hours. Complete resolution of the lesions was achieved five days after the first session. Once the diagnosis of virus-induced EM was confirmed, noninvasive techniques (e.g., salivary tests and aPDT) were very successful and can be indicated for managing these lesions.http://dx.doi.org/10.1155/2023/9938939
spellingShingle Fabiana Martins
Debora Pallos
Jodkandlys Candeia
Rodrigo Zerbinati
Paulo Henrique Braz-Silva
Luana Campos
Noninvasive Techniques for Management of Erythema Multiforme
Case Reports in Dentistry
title Noninvasive Techniques for Management of Erythema Multiforme
title_full Noninvasive Techniques for Management of Erythema Multiforme
title_fullStr Noninvasive Techniques for Management of Erythema Multiforme
title_full_unstemmed Noninvasive Techniques for Management of Erythema Multiforme
title_short Noninvasive Techniques for Management of Erythema Multiforme
title_sort noninvasive techniques for management of erythema multiforme
url http://dx.doi.org/10.1155/2023/9938939
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