Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's disease
Metabolic dysfunction-associated steatotic liver disease (MASLD) and Alzheimer’s disease (AD) are two growing epidemics across the globe. The two chronic, complex diseases have been increasingly linked through shared metabolic, inflammatory, and molecular pathways. Like many other complex diseases,...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Environmental Disease |
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| Online Access: | https://journals.lww.com/10.4103/ed.ed_5_25 |
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| author | Gary Zhang |
| author_facet | Gary Zhang |
| author_sort | Gary Zhang |
| collection | DOAJ |
| description | Metabolic dysfunction-associated steatotic liver disease (MASLD) and Alzheimer’s disease (AD) are two growing epidemics across the globe. The two chronic, complex diseases have been increasingly linked through shared metabolic, inflammatory, and molecular pathways. Like many other complex diseases, MASLD and AD are caused by the interaction between genetic and environmental factors. Chronic inflammation and metabolic dysregulation, two hallmark features of MASLD and AD, are associated with pathological factors, such as insulin resistance, dyslipidemia, endoplasmic reticulum stress, and oxidative stress in both diseases. The liver’s inflammatory state can contribute to neurodegenerative processes in AD, and vice versa, the neuronal dysregulation caused by AD condition profoundly affects whole body metabolism, which can lead to fatty liver disease. This review aims to provide a brief view of the current understanding of the metabolic and inflammatory links between MASLD and AD and the molecular players underlying these pathological conditions. |
| format | Article |
| id | doaj-art-e79772bfefb041989b3a533727aafcbc |
| institution | Kabale University |
| issn | 2468-5704 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Environmental Disease |
| spelling | doaj-art-e79772bfefb041989b3a533727aafcbc2025-08-20T03:31:33ZengWolters Kluwer Medknow PublicationsEnvironmental Disease2468-57042025-04-01102313510.4103/ed.ed_5_25Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's diseaseGary ZhangMetabolic dysfunction-associated steatotic liver disease (MASLD) and Alzheimer’s disease (AD) are two growing epidemics across the globe. The two chronic, complex diseases have been increasingly linked through shared metabolic, inflammatory, and molecular pathways. Like many other complex diseases, MASLD and AD are caused by the interaction between genetic and environmental factors. Chronic inflammation and metabolic dysregulation, two hallmark features of MASLD and AD, are associated with pathological factors, such as insulin resistance, dyslipidemia, endoplasmic reticulum stress, and oxidative stress in both diseases. The liver’s inflammatory state can contribute to neurodegenerative processes in AD, and vice versa, the neuronal dysregulation caused by AD condition profoundly affects whole body metabolism, which can lead to fatty liver disease. This review aims to provide a brief view of the current understanding of the metabolic and inflammatory links between MASLD and AD and the molecular players underlying these pathological conditions.https://journals.lww.com/10.4103/ed.ed_5_25alzheimer’s diseaseenvironmental riskinflammationmetabolic dysfunction-associated steatotic liver diseasemetabolism |
| spellingShingle | Gary Zhang Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's disease Environmental Disease alzheimer’s disease environmental risk inflammation metabolic dysfunction-associated steatotic liver disease metabolism |
| title | Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's disease |
| title_full | Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's disease |
| title_fullStr | Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's disease |
| title_full_unstemmed | Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's disease |
| title_short | Metabolic and inflammatory links between metabolic dysfunction-associated steatotic liver disease and Alzheimer's disease |
| title_sort | metabolic and inflammatory links between metabolic dysfunction associated steatotic liver disease and alzheimer s disease |
| topic | alzheimer’s disease environmental risk inflammation metabolic dysfunction-associated steatotic liver disease metabolism |
| url | https://journals.lww.com/10.4103/ed.ed_5_25 |
| work_keys_str_mv | AT garyzhang metabolicandinflammatorylinksbetweenmetabolicdysfunctionassociatedsteatoticliverdiseaseandalzheimersdisease |