OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION
Molecular genetic characteristics of the ovarian tumors can provide much quicker information about treatment effectiveness. The paper was aimed to study the frequency of BRCA1 5382insC mutation among ovarian cancer patients living in Siberia (the Tomsk region) and to detect the main clinical morphol...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/261 |
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| author | А. B. Villert L. А. Kolomiets N. S. Rodicheva А. А. Ivanova N. V. Cherdyntseva S. L. Stukanov |
| author_facet | А. B. Villert L. А. Kolomiets N. S. Rodicheva А. А. Ivanova N. V. Cherdyntseva S. L. Stukanov |
| author_sort | А. B. Villert |
| collection | DOAJ |
| description | Molecular genetic characteristics of the ovarian tumors can provide much quicker information about treatment effectiveness. The paper was aimed to study the frequency of BRCA1 5382insC mutation among ovarian cancer patients living in Siberia (the Tomsk region) and to detect the main clinical morphological and immunohistochemical characteristics of this disease. It was found that the frequency of BRCA1 5382insC mutation among ovarian cancer patients in the Tomsk region was 9.19 %. The partial response to platinum-based chemotherapy was observed in 75 % of ovarian cancer patients having BRCA1 5382insC mutation. Optimal cytoreduction is a significant predictor of the treatment effectiveness of hereditary ovarian cancer associated with BRCA1 5382insC mutation. |
| format | Article |
| id | doaj-art-e7963e25adb447baaa66e0e17cc8315f |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-e7963e25adb447baaa66e0e17cc8315f2025-08-20T02:59:11ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01061926261OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATIONА. B. Villert0L. А. Kolomiets1N. S. Rodicheva2А. А. Ivanova3N. V. Cherdyntseva4S. L. Stukanov5Tomsk Cancer Research Institute, TomskTomsk Cancer Research Institute, Tomsk Siberian State Medical University, TomskTomsk Cancer Research Institute, TomskTomsk Cancer Research Institute, TomskTomsk Cancer Research Institute, TomskTomsk Cancer Research Institute, TomskMolecular genetic characteristics of the ovarian tumors can provide much quicker information about treatment effectiveness. The paper was aimed to study the frequency of BRCA1 5382insC mutation among ovarian cancer patients living in Siberia (the Tomsk region) and to detect the main clinical morphological and immunohistochemical characteristics of this disease. It was found that the frequency of BRCA1 5382insC mutation among ovarian cancer patients in the Tomsk region was 9.19 %. The partial response to platinum-based chemotherapy was observed in 75 % of ovarian cancer patients having BRCA1 5382insC mutation. Optimal cytoreduction is a significant predictor of the treatment effectiveness of hereditary ovarian cancer associated with BRCA1 5382insC mutation.https://www.siboncoj.ru/jour/article/view/261ovarian cancerbrca1 5382insc mutationclinical morphological and immunohistochemical characteristicstreatment efficiency |
| spellingShingle | А. B. Villert L. А. Kolomiets N. S. Rodicheva А. А. Ivanova N. V. Cherdyntseva S. L. Stukanov OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION Сибирский онкологический журнал ovarian cancer brca1 5382insc mutation clinical morphological and immunohistochemical characteristics treatment efficiency |
| title | OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION |
| title_full | OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION |
| title_fullStr | OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION |
| title_full_unstemmed | OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION |
| title_short | OVARIAN CANCER IN PATIENTS WITH BRCA1 5382insC MUTATION |
| title_sort | ovarian cancer in patients with brca1 5382insc mutation |
| topic | ovarian cancer brca1 5382insc mutation clinical morphological and immunohistochemical characteristics treatment efficiency |
| url | https://www.siboncoj.ru/jour/article/view/261 |
| work_keys_str_mv | AT abvillert ovariancancerinpatientswithbrca15382inscmutation AT lakolomiets ovariancancerinpatientswithbrca15382inscmutation AT nsrodicheva ovariancancerinpatientswithbrca15382inscmutation AT aaivanova ovariancancerinpatientswithbrca15382inscmutation AT nvcherdyntseva ovariancancerinpatientswithbrca15382inscmutation AT slstukanov ovariancancerinpatientswithbrca15382inscmutation |