SHED-derived exosome-mimetics promotes rotator cuff tendon-bone healing via macrophage immunomodulation through NF-κB suppression and autophagy activation

SHED-derived exosome-mimetics promotes rotator cuff tendon-bone healing via macrophage immunomodulation through NF-κB suppression and autophagy activation

Rotator cuff tendon-bone healing is impeded by inflammation and inadequate regeneration. This study evaluates exosome-mimetics (EMs) derived from stem cells of human exfoliated deciduous teeth (SHEDs) as a therapeutic strategy to enhance repair.SHED-EMs were synthesized via serial extrusion and char...

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Bibliographic Details
Main Authors: Yanwei He, Junzhe Sheng, Fashun Liu, Fangqi Li, Shihao Lu, Wenbo Chen, Li Yang, Peng Zhou, Zan Chen, Shiyi Chen, Zhiwen Luo, Junming Sun
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Bioactive materials
Exosome-mimetics
Macrophages
Immunomodulation
Rotator cuff tear
Tendon-to-bone healing
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007161
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