Protective Effect of Fenugreek Supplementation against Mercury Toxicity on Sperm Parameters, Serum Testosterone and Testicular Tissue in the Rat
Background and objectives:The purpose of the current study was to investigate the effects of fenugreek supplementation against toxic effect of mercuric chloride (HgCl2)on Body weight (B.W), testis and epididymis weight, some sperm parameters, serum testosterone, serum MDA, and testis histology in th...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Erbil Polytechnic University
2023-09-01
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| Series: | Polytechnic Journal |
| Subjects: | |
| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol13/iss1/19 |
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| Summary: | Background and objectives:The purpose of the current study was to investigate the effects of fenugreek
supplementation against toxic effect of mercuric chloride (HgCl2)on Body weight (B.W), testis and
epididymis weight, some sperm parameters, serum testosterone, serum MDA, and testis histology in the
rat.Methods: Twenty eight male albino rats weights ranging from 254 to 302 gm and were divided
randomly and equally into 4 groups. Group I: control, Group II: Rats received drinking water contained
HgCl2 100 mg/L ad libitum, Group III: Rats received drinking water contained HgCl2 100 mg/L ad libitum,
and fenugreek (F1) 0.75 mg/kg/day orally by gavage, Group IV: Rats received drinking water contained
HgCl2 100 mg/L ad libitumand fenugreek (F2) 1.5 mg/kg/day orally by gavage. The treatments were given
for six weeks.Results: Treatment with F1 caused no substantial changes in body weight, absolute weight,
andrelative weight of testis and epididymis, sperm count and testosterone. Whereas sperm motility, and
normal sperm were increased significantly, and serum MDA was decreased significantly from HgCl2
group. Improvement was observed partially in testis histology. Meanwhile, the protective effect in F2
generally was more than in F1.Conclusions: the present study revealed that the antioxidant activity of
fenugreek supplementreduced toxic effect of mercury. In addition, steroids and/or phytoestrogens in
fenugreek possibly compensated the reduced testosterone which resulted at least in part in improvement
of sperm parameters and testis histology |
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| ISSN: | 2707-7799 |