Impact of Oxidative Stress in Fetal Programming
Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling f...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2012/582748 |
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| _version_ | 1850167586540486656 |
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| author | Loren P. Thompson Yazan Al-Hasan |
| author_facet | Loren P. Thompson Yazan Al-Hasan |
| author_sort | Loren P. Thompson |
| collection | DOAJ |
| description | Intrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress with dysregulation of specific target genes, we may be able to develop therapeutic strategies that protect against organ dysfunction in the programmed offspring. |
| format | Article |
| id | doaj-art-e78795cfcd6e422986db1573745626c4 |
| institution | OA Journals |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-e78795cfcd6e422986db1573745626c42025-08-20T02:21:10ZengWileyJournal of Pregnancy2090-27272090-27352012-01-01201210.1155/2012/582748582748Impact of Oxidative Stress in Fetal ProgrammingLoren P. Thompson0Yazan Al-Hasan1Department of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 11-029 Bressler Research Building, 655 W. Baltimore Street, Baltimore, MD 21201, USADepartment of Obstetrics, Gynecology and Reproductive Sciences, University of Maryland School of Medicine, 11-029 Bressler Research Building, 655 W. Baltimore Street, Baltimore, MD 21201, USAIntrauterine stress induces increased risk of adult disease through fetal programming mechanisms. Oxidative stress can be generated by several conditions, such as, prenatal hypoxia, maternal under- and overnutrition, and excessive glucocorticoid exposure. The role of oxidant molecules as signaling factors in fetal programming via epigenetic mechanisms is discussed. By linking oxidative stress with dysregulation of specific target genes, we may be able to develop therapeutic strategies that protect against organ dysfunction in the programmed offspring.http://dx.doi.org/10.1155/2012/582748 |
| spellingShingle | Loren P. Thompson Yazan Al-Hasan Impact of Oxidative Stress in Fetal Programming Journal of Pregnancy |
| title | Impact of Oxidative Stress in Fetal Programming |
| title_full | Impact of Oxidative Stress in Fetal Programming |
| title_fullStr | Impact of Oxidative Stress in Fetal Programming |
| title_full_unstemmed | Impact of Oxidative Stress in Fetal Programming |
| title_short | Impact of Oxidative Stress in Fetal Programming |
| title_sort | impact of oxidative stress in fetal programming |
| url | http://dx.doi.org/10.1155/2012/582748 |
| work_keys_str_mv | AT lorenpthompson impactofoxidativestressinfetalprogramming AT yazanalhasan impactofoxidativestressinfetalprogramming |