Imipramine-induced immunomodulation and intracellular growth inhibition during Brucella abortus 544 infection in RAW 264.7 cells and BALB/c mice

Imipramine-induced immunomodulation and intracellular growth inhibition during Brucella abortus 544 infection in RAW 264.7 cells and BALB/c mice

Brucellosis is a significant zoonotic infection with increasing global prevalence. Traditional treatments rely on antibiotic combinations, but challenges such as drug resistance and relapse necessitate the exploration of alternative therapeutic options. Imipramine hydrochloride (ImiP) has shown pote...

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Bibliographic Details
Main Authors: Ched Nicole Turbela Aguilar, Tran Xuan Ngoc Huy, Trang Thi Nguyen, Said Abdi Salad, Seong Eun Cho, Il-Hwa Hong, Wongi Min, Hu Jang Lee, Suk Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Veterinary Science
Subjects:
Brucella abortus
imipramine hydrochloride
BALB/c mouse
RAW 264.7 cells
immunomodulation
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1598106/full
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