Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction
We hypothesized that redox analysis could provide sensitive markers of the oxidative pathway associated to the presence of an increasing number of cardiovascular risk factors (RFs), independently of type. We classified 304 subjects without cardiovascular disease into 4 groups according to the total...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/303654 |
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| author | Benedetta De Chiara Valentina Sedda Marina Parolini Jonica Campolo Renata De Maria Raffaele Caruso Gianluigi Pizzi Olga Disoteo Cinzia Dellanoce Anna Rosa Corno Giuliana Cighetti Oberdan Parodi |
| author_facet | Benedetta De Chiara Valentina Sedda Marina Parolini Jonica Campolo Renata De Maria Raffaele Caruso Gianluigi Pizzi Olga Disoteo Cinzia Dellanoce Anna Rosa Corno Giuliana Cighetti Oberdan Parodi |
| author_sort | Benedetta De Chiara |
| collection | DOAJ |
| description | We hypothesized that redox analysis could provide sensitive markers of the oxidative pathway associated to the presence of an increasing number of cardiovascular risk factors (RFs), independently of type. We classified 304 subjects without cardiovascular disease into 4 groups according to the total number of RFs (smoking, hypertension, hypercholesterolaemia, hyperhomocysteinaemia, diabetes, obesity, and their combination). Oxidative stress was evaluated by measuring plasma total and reduced homocysteine, cysteine (Cys), glutathione, cysteinylglycine, blood reduced glutathione, and malondialdehyde. Twenty-seven percent of subjects were in group 0 RF, 26% in 1 RF, 31% in 2 RF, and 16% in ≥3 RF. By multivariable ordinal regression analysis, plasma total Cys was associated to a higher number of RF (OR = 1.068; 95% CI = 1.027–1.110, 𝑃=0.002). Total RF burden is associated with increased total Cys levels. These findings support a prooxidant effect of Cys in conjunction with RF burden, and shed light on the pathophysiologic role of redox state unbalance in preclinical atherosclerosis. |
| format | Article |
| id | doaj-art-e783164c0d734063865459b21f3cb326 |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e783164c0d734063865459b21f3cb3262025-08-20T02:21:10ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/303654303654Plasma Total Cysteine and Cardiovascular Risk Burden: Action and InteractionBenedetta De Chiara0Valentina Sedda1Marina Parolini2Jonica Campolo3Renata De Maria4Raffaele Caruso5Gianluigi Pizzi6Olga Disoteo7Cinzia Dellanoce8Anna Rosa Corno9Giuliana Cighetti10Oberdan Parodi11CNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyDiabetologic and Metabolic Unit, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyDiabetologic and Metabolic Unit, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyDepartment of Clinical Sciences “Luigi Sacco”, University of Milan, 20157 Milan, ItalyCNR Clinical Physiology Institute and Cardiovascular Department, Niguarda Ca' Granda Hospital, 20162 Milan, ItalyWe hypothesized that redox analysis could provide sensitive markers of the oxidative pathway associated to the presence of an increasing number of cardiovascular risk factors (RFs), independently of type. We classified 304 subjects without cardiovascular disease into 4 groups according to the total number of RFs (smoking, hypertension, hypercholesterolaemia, hyperhomocysteinaemia, diabetes, obesity, and their combination). Oxidative stress was evaluated by measuring plasma total and reduced homocysteine, cysteine (Cys), glutathione, cysteinylglycine, blood reduced glutathione, and malondialdehyde. Twenty-seven percent of subjects were in group 0 RF, 26% in 1 RF, 31% in 2 RF, and 16% in ≥3 RF. By multivariable ordinal regression analysis, plasma total Cys was associated to a higher number of RF (OR = 1.068; 95% CI = 1.027–1.110, 𝑃=0.002). Total RF burden is associated with increased total Cys levels. These findings support a prooxidant effect of Cys in conjunction with RF burden, and shed light on the pathophysiologic role of redox state unbalance in preclinical atherosclerosis.http://dx.doi.org/10.1100/2012/303654 |
| spellingShingle | Benedetta De Chiara Valentina Sedda Marina Parolini Jonica Campolo Renata De Maria Raffaele Caruso Gianluigi Pizzi Olga Disoteo Cinzia Dellanoce Anna Rosa Corno Giuliana Cighetti Oberdan Parodi Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction The Scientific World Journal |
| title | Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction |
| title_full | Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction |
| title_fullStr | Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction |
| title_full_unstemmed | Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction |
| title_short | Plasma Total Cysteine and Cardiovascular Risk Burden: Action and Interaction |
| title_sort | plasma total cysteine and cardiovascular risk burden action and interaction |
| url | http://dx.doi.org/10.1100/2012/303654 |
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