Coumarin: A natural solution for alleviating inflammatory disorders
Coumarin, a naturally occurring compound found in various plants, has a rich history of use in traditional medicine. Recent research has highlighted its anti-inflammatory properties, positioning it as a promising candidate for treating inflammatory disorders such as rheumatoid arthritis, asthma, and...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Current Research in Pharmacology and Drug Discovery |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590257124000294 |
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| author | Farnoosh Saadati Amir Modarresi Chahardehi Negar Jamshidi Nazanin Jamshidi Darioush Ghasemi |
| author_facet | Farnoosh Saadati Amir Modarresi Chahardehi Negar Jamshidi Nazanin Jamshidi Darioush Ghasemi |
| author_sort | Farnoosh Saadati |
| collection | DOAJ |
| description | Coumarin, a naturally occurring compound found in various plants, has a rich history of use in traditional medicine. Recent research has highlighted its anti-inflammatory properties, positioning it as a promising candidate for treating inflammatory disorders such as rheumatoid arthritis, asthma, and inflammatory bowel disease. This narrative review aims to comprehensively summarize the current knowledge regarding coumarin's pharmacological effects in alleviating inflammatory conditions by analyzing preclinical and clinical studies. The review focuses on elucidating the mechanisms through which coumarin exerts its anti-inflammatory effects, including its antioxidant activity, inhibiting pro-inflammatory cytokine production, and modulation of immune cell functions. Additionally, the paper addresses potential limitations of using coumarin, such as concerns about toxicity at high doses or with prolonged use. Before widespread clinical application, further investigation is needed to fully understand coumarin's potential benefits and risks. |
| format | Article |
| id | doaj-art-e78306135a1a44daad8aab44871c449c |
| institution | OA Journals |
| issn | 2590-2571 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Pharmacology and Drug Discovery |
| spelling | doaj-art-e78306135a1a44daad8aab44871c449c2025-08-20T02:37:46ZengElsevierCurrent Research in Pharmacology and Drug Discovery2590-25712024-01-01710020210.1016/j.crphar.2024.100202Coumarin: A natural solution for alleviating inflammatory disordersFarnoosh Saadati0Amir Modarresi Chahardehi1Negar Jamshidi2Nazanin Jamshidi3Darioush Ghasemi4Department of Cellular and Molecular Biology, Islamic Azad University, Tehran Medical Branch, Tehran, IranKimia Andisheh Teb Medical and Molecular Research Laboratory Co., Tehran, Iran; Corresponding author.Kimia Andisheh Teb Medical and Molecular Research Laboratory Co., Tehran, IranKimia Andisheh Teb Medical and Molecular Research Laboratory Co., Tehran, IranKimia Andisheh Teb Medical and Molecular Research Laboratory Co., Tehran, IranCoumarin, a naturally occurring compound found in various plants, has a rich history of use in traditional medicine. Recent research has highlighted its anti-inflammatory properties, positioning it as a promising candidate for treating inflammatory disorders such as rheumatoid arthritis, asthma, and inflammatory bowel disease. This narrative review aims to comprehensively summarize the current knowledge regarding coumarin's pharmacological effects in alleviating inflammatory conditions by analyzing preclinical and clinical studies. The review focuses on elucidating the mechanisms through which coumarin exerts its anti-inflammatory effects, including its antioxidant activity, inhibiting pro-inflammatory cytokine production, and modulation of immune cell functions. Additionally, the paper addresses potential limitations of using coumarin, such as concerns about toxicity at high doses or with prolonged use. Before widespread clinical application, further investigation is needed to fully understand coumarin's potential benefits and risks.http://www.sciencedirect.com/science/article/pii/S2590257124000294CoumarinAnti-inflammatoryHerbal medicineBioactive compoundCytokine |
| spellingShingle | Farnoosh Saadati Amir Modarresi Chahardehi Negar Jamshidi Nazanin Jamshidi Darioush Ghasemi Coumarin: A natural solution for alleviating inflammatory disorders Current Research in Pharmacology and Drug Discovery Coumarin Anti-inflammatory Herbal medicine Bioactive compound Cytokine |
| title | Coumarin: A natural solution for alleviating inflammatory disorders |
| title_full | Coumarin: A natural solution for alleviating inflammatory disorders |
| title_fullStr | Coumarin: A natural solution for alleviating inflammatory disorders |
| title_full_unstemmed | Coumarin: A natural solution for alleviating inflammatory disorders |
| title_short | Coumarin: A natural solution for alleviating inflammatory disorders |
| title_sort | coumarin a natural solution for alleviating inflammatory disorders |
| topic | Coumarin Anti-inflammatory Herbal medicine Bioactive compound Cytokine |
| url | http://www.sciencedirect.com/science/article/pii/S2590257124000294 |
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