Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom
Objective. To reveal frequency of reactivation of persistent HSV type 1, 2 and CMV infections and to estimate its role in pathogenesis of rheumatoid uveitis in children with JCA. Material and methods. 61 children with RU at the age of 5 - 15 years were studied. The duration of disease: 6 months - 13...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2003-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/1552 |
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| author | G. L. Krichevskaya V O Andjelov L A Katargina A. V. Starikova A J Zvonarev M N Kulyakina N P Tsutskiridze A V Chvatova I Z Zaitsev |
| author_facet | G. L. Krichevskaya V O Andjelov L A Katargina A. V. Starikova A J Zvonarev M N Kulyakina N P Tsutskiridze A V Chvatova I Z Zaitsev |
| author_sort | G. L. Krichevskaya |
| collection | DOAJ |
| description | Objective. To reveal frequency of reactivation of persistent HSV type 1, 2 and CMV infections and to estimate its role in pathogenesis of rheumatoid uveitis in children with JCA. Material and methods. 61 children with RU at the age of 5 - 15 years were studied. The duration of disease: 6 months - 13 years. Serum samples were tested in commercial enzyme linked immunnosorbent assay for detection of antibodies to unstructural early herpesviruses proteins (serologic evidence of acute infection). Cell-mediated immunity to HSV was measured by the in vitro proliferated response of peripheral lymphocytes (LP). Results. Reactivation of HSV and/or CMV persistent infections was established in 30 of 61 surveyed children (49 %) with RU. The activation of HSV type 1 infection (34,4 % of the patients) dominated. The antibodies to unstructured early HSV type 2 protein were detected in 8,2 %, to CMV- in 5 % of children. Conclusion. The correlation was observed between results of serologic investigations and clinical signs of RU. |
| format | Article |
| id | doaj-art-e78121ce86cd40c583669987f26822a6 |
| institution | Kabale University |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2003-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-e78121ce86cd40c583669987f26822a62025-08-20T03:38:34ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922003-02-01411707210.14412/1995-4484-2003-11401489Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritomG. L. KrichevskayaV O AndjelovL A KatarginaA. V. StarikovaA J ZvonarevM N KulyakinaN P TsutskiridzeA V ChvatovaI Z ZaitsevObjective. To reveal frequency of reactivation of persistent HSV type 1, 2 and CMV infections and to estimate its role in pathogenesis of rheumatoid uveitis in children with JCA. Material and methods. 61 children with RU at the age of 5 - 15 years were studied. The duration of disease: 6 months - 13 years. Serum samples were tested in commercial enzyme linked immunnosorbent assay for detection of antibodies to unstructural early herpesviruses proteins (serologic evidence of acute infection). Cell-mediated immunity to HSV was measured by the in vitro proliferated response of peripheral lymphocytes (LP). Results. Reactivation of HSV and/or CMV persistent infections was established in 30 of 61 surveyed children (49 %) with RU. The activation of HSV type 1 infection (34,4 % of the patients) dominated. The antibodies to unstructured early HSV type 2 protein were detected in 8,2 %, to CMV- in 5 % of children. Conclusion. The correlation was observed between results of serologic investigations and clinical signs of RU.https://rsp.mediar-press.net/rsp/article/view/1552juvenile chronic arthritisuveitisherpesvirusescytomegalovirus |
| spellingShingle | G. L. Krichevskaya V O Andjelov L A Katargina A. V. Starikova A J Zvonarev M N Kulyakina N P Tsutskiridze A V Chvatova I Z Zaitsev Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom Научно-практическая ревматология juvenile chronic arthritis uveitis herpesviruses cytomegalovirus |
| title | Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom |
| title_full | Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom |
| title_fullStr | Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom |
| title_full_unstemmed | Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom |
| title_short | Opportunisticheskaya gerpes-virusnaya infektsiya v patogeneze uveitov u detey s yuvenil'nym khronicheskim artritom |
| title_sort | opportunisticheskaya gerpes virusnaya infektsiya v patogeneze uveitov u detey s yuvenil nym khronicheskim artritom |
| topic | juvenile chronic arthritis uveitis herpesviruses cytomegalovirus |
| url | https://rsp.mediar-press.net/rsp/article/view/1552 |
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