Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational study
Objective We aimed to evaluate the association of intrahepatic triglyceride (IHTG) content in subjects with metabolically healthy abdominal obesity (MHAO) on risks of pre-diabetes plus diabetes.Design Cross-sectional survey.Setting Lianqian community, the First Affiliated Hospital of Xiamen Universi...
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BMJ Publishing Group
2022-02-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/2/e057820.full |
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| author | Junfeng Zhang Wei Zhang Changqin Liu Mingzhu Lin Ning Chen Caoxin Huang Qiaoyan Xu Fangfang Lai Yongwen Liu Shunqin Wang Zhibin Li Haiwei Han |
| author_facet | Junfeng Zhang Wei Zhang Changqin Liu Mingzhu Lin Ning Chen Caoxin Huang Qiaoyan Xu Fangfang Lai Yongwen Liu Shunqin Wang Zhibin Li Haiwei Han |
| author_sort | Junfeng Zhang |
| collection | DOAJ |
| description | Objective We aimed to evaluate the association of intrahepatic triglyceride (IHTG) content in subjects with metabolically healthy abdominal obesity (MHAO) on risks of pre-diabetes plus diabetes.Design Cross-sectional survey.Setting Lianqian community, the First Affiliated Hospital of Xiamen University, Xiamen, China.Participants Among 1523 community-living healthy adults aged 40 years or older with abdominal obesity recruited at baseline, 428 subjects who underwent IHTG content measurement were selected.Outcome measures Risk of pre-diabetes plus diabetes.Results Non-alcoholic fatty liver disease (NAFLD) was diagnosed as 203 (69.1%) in MHAO and 121 (90.3%) in metabolically unhealthy abdominal obesity (MUAO) (p<0.001). The prevalence rates of pre-diabetes plus diabetes were 81.1%, 88.8% and 90.9% across the tertiles of IHTG content (p=0.037). Both MUAO (vs MHAO) and NAFLD (vs non-NAFLD) were independently associated with increased risks of pre-diabetes plus diabetes, the adjusted ORs (95% CIs) were 10.90 (3.15 to 37.69, p<0.001) and 3.02 (1.47 to 6.20, p=0.003), respectively. Higher IHTG content was significantly associated with increased risk of pre-diabetes plus diabetes with the adjusted OR (95% CI) of per SD increase of IHTG content of 1.62 (1.07 to 2.46, p=0.024). And there was a significantly positive trend between increasing categories of IHTG content tertiles and excessive risks of pre-diabetes plus diabetes (trend test p value=0.011). Stratified analyses showed similar results on the associations of NAFLD and IHTG content with risks of pre-diabetes plus diabetes for subjects with MHAO but not for those with MUAO.Conclusions NAFLD and higher IHTG content were independently associated with increased risks of pre-diabetes plus diabetes in MHAO subjects. NAFLD or quantity of liver fat should be considered as additional criterion when defining and diagnosing MHO. Screening of NAFLD and intervention to reduce liver fat should be strengthened even for those seemly metabolically healthy obese. |
| format | Article |
| id | doaj-art-e77a64d7253c44d5b5f9380fc1812556 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2022-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-e77a64d7253c44d5b5f9380fc18125562025-08-20T03:48:42ZengBMJ Publishing GroupBMJ Open2044-60552022-02-0112210.1136/bmjopen-2021-057820Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational studyJunfeng Zhang0Wei Zhang1Changqin Liu2Mingzhu Lin3Ning Chen4Caoxin Huang5Qiaoyan Xu6Fangfang Lai7Yongwen Liu8Shunqin Wang9Zhibin Li10Haiwei Han111 State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu, China6 Teaching Department, Hangzhou Normal University Affiliated Hospital, Hangzhou, Zhejiang, ChinaDepartment of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaDepartment of Endocrinology and Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaDepartment of Endocrinology, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, ChinaDepartment of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaLianqian Community Health Service Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaLianqian Community Health Service Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaDepartment of Nursing, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaKey laboratory of Neonatal Diseases, Children’s Hospital of Fudan University Xiamen Branch, Xiamen, Fujian, ChinaEpidemiology Research Unit, Translational Medicine Research Center, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, ChinaDepartment of Radiology, The First Affiliated Hospital of Xiamen University, School of medicine, Xiamen university, Xiamen, ChinaObjective We aimed to evaluate the association of intrahepatic triglyceride (IHTG) content in subjects with metabolically healthy abdominal obesity (MHAO) on risks of pre-diabetes plus diabetes.Design Cross-sectional survey.Setting Lianqian community, the First Affiliated Hospital of Xiamen University, Xiamen, China.Participants Among 1523 community-living healthy adults aged 40 years or older with abdominal obesity recruited at baseline, 428 subjects who underwent IHTG content measurement were selected.Outcome measures Risk of pre-diabetes plus diabetes.Results Non-alcoholic fatty liver disease (NAFLD) was diagnosed as 203 (69.1%) in MHAO and 121 (90.3%) in metabolically unhealthy abdominal obesity (MUAO) (p<0.001). The prevalence rates of pre-diabetes plus diabetes were 81.1%, 88.8% and 90.9% across the tertiles of IHTG content (p=0.037). Both MUAO (vs MHAO) and NAFLD (vs non-NAFLD) were independently associated with increased risks of pre-diabetes plus diabetes, the adjusted ORs (95% CIs) were 10.90 (3.15 to 37.69, p<0.001) and 3.02 (1.47 to 6.20, p=0.003), respectively. Higher IHTG content was significantly associated with increased risk of pre-diabetes plus diabetes with the adjusted OR (95% CI) of per SD increase of IHTG content of 1.62 (1.07 to 2.46, p=0.024). And there was a significantly positive trend between increasing categories of IHTG content tertiles and excessive risks of pre-diabetes plus diabetes (trend test p value=0.011). Stratified analyses showed similar results on the associations of NAFLD and IHTG content with risks of pre-diabetes plus diabetes for subjects with MHAO but not for those with MUAO.Conclusions NAFLD and higher IHTG content were independently associated with increased risks of pre-diabetes plus diabetes in MHAO subjects. NAFLD or quantity of liver fat should be considered as additional criterion when defining and diagnosing MHO. Screening of NAFLD and intervention to reduce liver fat should be strengthened even for those seemly metabolically healthy obese.https://bmjopen.bmj.com/content/12/2/e057820.full |
| spellingShingle | Junfeng Zhang Wei Zhang Changqin Liu Mingzhu Lin Ning Chen Caoxin Huang Qiaoyan Xu Fangfang Lai Yongwen Liu Shunqin Wang Zhibin Li Haiwei Han Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational study BMJ Open |
| title | Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational study |
| title_full | Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational study |
| title_fullStr | Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational study |
| title_full_unstemmed | Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational study |
| title_short | Association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre-diabetes plus diabetes: an observational study |
| title_sort | association between intrahepatic triglyceride content in subjects with metabolically healthy abdominal obesity and risks of pre diabetes plus diabetes an observational study |
| url | https://bmjopen.bmj.com/content/12/2/e057820.full |
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