Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance
Several natural components abundant in the fluid phase of human breast-milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and oth...
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Mediators of Inflammation |
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| Online Access: | http://dx.doi.org/10.1080/09629359990559 |
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| _version_ | 1832566998841688064 |
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| author | Michael Oladipo Ogundele |
| author_facet | Michael Oladipo Ogundele |
| author_sort | Michael Oladipo Ogundele |
| collection | DOAJ |
| description | Several natural components abundant in the fluid phase of human breast-milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement activation. Their physiological significance probably resides in their ability to restrict in vivo complement activation to specialized (compartmentalized) sites on the cellular membrane structures in human milk, represented by the abundant surface area of the milk fat globule membranes. This would serve to prevent inflammatory-induced tissue damage of the delicate immature gastrointestinal tract of the newborn as well as the mammary gland itself. A number of recognized and potential inhibitors of complement activity in human milk and other biological fluids are hereby reviewed, with a proposal of their physiological significance. |
| format | Article |
| id | doaj-art-e77a05b547e644ca89a38a960f2643ee |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-e77a05b547e644ca89a38a960f2643ee2025-02-03T01:02:42ZengWileyMediators of Inflammation0962-93511466-18611999-01-0182697510.1080/09629359990559Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological SignificanceMichael Oladipo Ogundele0Department of Immunology, Georg-August University, Kreuzbergring 57, Göttingen D-37075, GermanySeveral natural components abundant in the fluid phase of human breast-milk have been shown to be inhibitors of complement activation in vitro, particularly the classical pathway. These include lysozyme, lactoferrin, lactalbumin alpha and other ligand chelators, complement regulator proteins and other specific soluble inhibitors of complement activation. Their physiological significance probably resides in their ability to restrict in vivo complement activation to specialized (compartmentalized) sites on the cellular membrane structures in human milk, represented by the abundant surface area of the milk fat globule membranes. This would serve to prevent inflammatory-induced tissue damage of the delicate immature gastrointestinal tract of the newborn as well as the mammary gland itself. A number of recognized and potential inhibitors of complement activity in human milk and other biological fluids are hereby reviewed, with a proposal of their physiological significance.http://dx.doi.org/10.1080/09629359990559Human breast-milkcomplement systeminhibitorsmilk fat globule membrane. |
| spellingShingle | Michael Oladipo Ogundele Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance Mediators of Inflammation Human breast-milk complement system inhibitors milk fat globule membrane. |
| title | Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance |
| title_full | Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance |
| title_fullStr | Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance |
| title_full_unstemmed | Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance |
| title_short | Inhibitors of Complement Activity in Human Breast-Milk: A Proposed Hypothesis of Their Physiological Significance |
| title_sort | inhibitors of complement activity in human breast milk a proposed hypothesis of their physiological significance |
| topic | Human breast-milk complement system inhibitors milk fat globule membrane. |
| url | http://dx.doi.org/10.1080/09629359990559 |
| work_keys_str_mv | AT michaeloladipoogundele inhibitorsofcomplementactivityinhumanbreastmilkaproposedhypothesisoftheirphysiologicalsignificance |