Differential changes in the microglial transcriptome between neonatal and adult mice after spinal cord injury

Differential changes in the microglial transcriptome between neonatal and adult mice after spinal cord injury

Abstract Spinal cord injury (SCI) remains a significant therapeutic challenge, lacking effective treatment options. Related studies have found that neonatal microglia are more effective than adult microglia in promoting the recovery of SCI, but the reason why neonatal, not adult, microglia are more...

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Bibliographic Details
Main Authors: Qi Jiang, Shiyuan Xue, Xiaojing Pan, Tengbo Yu, Xinyi Wei, Liping Li, Chao Qi, Weipeng Shi, Zhongkai Ren, Die Hu, Haitao Fu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Subjects:
Spinal cord injury
Microglia
Transcriptome sequencing
Bioinformatics
Quantitative real-time polymerase chain reaction.
Online Access:https://doi.org/10.1038/s41598-025-98429-7
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