Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics

Comprehensive single-cell pan-cancer atlas unveils IFI30+ macrophages as key modulators of intra-tumoral immune dynamics

BackgroundThe convergence of macrophage-targeted strategies with immune checkpoint blockade therapies defines a pivotal avenue in contemporary tumor therapy. Identifying robust genetic regulators in this context is imperative.MethodsThis study elucidates IFI30's role in enhancing Major Histocom...

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Bibliographic Details
Main Authors: Lihe Jiang, Peili Wang, Yixuan Hou, Jingying Chen, Hua Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
IFI30
scRNA-seq
spatial transcriptomics
pan-cancer
macrophage
immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1523854/full
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