Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review
Cyclophosphamide-induced cardiotoxicity, associated with its toxic metabolite acrolein, is a significant concern and unresolved issue, especially when cyclophosphamide is administrated in high doses. However, cardiotoxicity following low-dose cyclophosphamide has been also documented, especially in...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2024-12-01
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| Series: | Journal of Cardiovascular and Thoracic Research |
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| Online Access: | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-211.pdf |
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| author | Azin Alizadehasl Bita Shahrami Reza Rahbarghazi Azam Yalameh Aliabadi Seyedeh Fatemeh Hosseini Jebelli Yasamin Afsari Zonooz Hoda Hakimian Farzaneh Fathi Sara Forati Aysa Rezabakhsh |
| author_facet | Azin Alizadehasl Bita Shahrami Reza Rahbarghazi Azam Yalameh Aliabadi Seyedeh Fatemeh Hosseini Jebelli Yasamin Afsari Zonooz Hoda Hakimian Farzaneh Fathi Sara Forati Aysa Rezabakhsh |
| author_sort | Azin Alizadehasl |
| collection | DOAJ |
| description | Cyclophosphamide-induced cardiotoxicity, associated with its toxic metabolite acrolein, is a significant concern and unresolved issue, especially when cyclophosphamide is administrated in high doses. However, cardiotoxicity following low-dose cyclophosphamide has been also documented, especially in post-hematopoietic stem cell transplantation (post-HSCT) settings. Despite the involvement of multiple signaling pathways in cyclophosphamide-induced cardiomyopathy, the exact underlying mechanisms remain to be fully elucidated. This review outlines the current challenges of cyclophosphamide therapy in HSCT recipients. In addition, the promising therapeutic approaches by targeting acrolein’s anti-angiogenic effect were thoroughly discussed to better manage post-HSCT cyclophosphamide-induced cardiotoxicity. |
| format | Article |
| id | doaj-art-e778d2791b4c40709e4336018ee80d7a |
| institution | DOAJ |
| issn | 2008-5117 2008-6830 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Cardiovascular and Thoracic Research |
| spelling | doaj-art-e778d2791b4c40709e4336018ee80d7a2025-08-20T02:46:20ZengTabriz University of Medical SciencesJournal of Cardiovascular and Thoracic Research2008-51172008-68302024-12-0116421122110.34172/jcvtr.33230jcvtr-33230Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive reviewAzin Alizadehasl0Bita Shahrami1Reza Rahbarghazi2Azam Yalameh Aliabadi3Seyedeh Fatemeh Hosseini Jebelli4Yasamin Afsari Zonooz5Hoda Hakimian6Farzaneh Fathi7Sara Forati8Aysa Rezabakhsh9Cardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, IranDepartment of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, IranCardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, IranCardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, IranCardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, IranCardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, IranPharmaceutical Sciences Research Center, Ardabil University of Medical Sciences, Ardabil, IranCardio-Oncology Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, IranCardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, IranCyclophosphamide-induced cardiotoxicity, associated with its toxic metabolite acrolein, is a significant concern and unresolved issue, especially when cyclophosphamide is administrated in high doses. However, cardiotoxicity following low-dose cyclophosphamide has been also documented, especially in post-hematopoietic stem cell transplantation (post-HSCT) settings. Despite the involvement of multiple signaling pathways in cyclophosphamide-induced cardiomyopathy, the exact underlying mechanisms remain to be fully elucidated. This review outlines the current challenges of cyclophosphamide therapy in HSCT recipients. In addition, the promising therapeutic approaches by targeting acrolein’s anti-angiogenic effect were thoroughly discussed to better manage post-HSCT cyclophosphamide-induced cardiotoxicity.https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-211.pdfangiogenesisacroleincardiotoxicitycyclophosphamidehematopoietic stem cell transplantation |
| spellingShingle | Azin Alizadehasl Bita Shahrami Reza Rahbarghazi Azam Yalameh Aliabadi Seyedeh Fatemeh Hosseini Jebelli Yasamin Afsari Zonooz Hoda Hakimian Farzaneh Fathi Sara Forati Aysa Rezabakhsh Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review Journal of Cardiovascular and Thoracic Research angiogenesis acrolein cardiotoxicity cyclophosphamide hematopoietic stem cell transplantation |
| title | Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review |
| title_full | Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review |
| title_fullStr | Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review |
| title_full_unstemmed | Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review |
| title_short | Post-transplant cyclophosphamide-induced cardiotoxicity: A comprehensive review |
| title_sort | post transplant cyclophosphamide induced cardiotoxicity a comprehensive review |
| topic | angiogenesis acrolein cardiotoxicity cyclophosphamide hematopoietic stem cell transplantation |
| url | https://jcvtr.tbzmed.ac.ir/PDF/jcvtr-16-211.pdf |
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