The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells
Inflammation is known to be closely associated with the development of cancer. The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resource Arca subcrenata. The basic rese...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/768938 |
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| author | Yu Wu Xianjing Hu Liyan Song Jianhua Zhu Rongmin Yu |
| author_facet | Yu Wu Xianjing Hu Liyan Song Jianhua Zhu Rongmin Yu |
| author_sort | Yu Wu |
| collection | DOAJ |
| description | Inflammation is known to be closely associated with the development of cancer. The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resource Arca subcrenata. The basic research showed that P2 could suppress the production of nitric oxide in LPS-induced RAW264.7 macrophage cells as well as the secretion of inflammatory cytokines IL-6 and TNF-α in human cervical cancer HeLa cells. For the molecular mechanisms, P2 was shown to downregulate the gene expression of proinflammatory cytokines IL-6 and IL-8 and to inhibit the COX-2 and iNOS-related pathways in HeLa cells. In consequence, P2 might inhibit tumor development by blocking the interaction between tumor microenvironment and proinflammatory mediators. All findings indicate that P2 possesses the potential to be developed as a novel agent for cancer therapy. |
| format | Article |
| id | doaj-art-e7786e057c384cd08f74846d9463fe06 |
| institution | OA Journals |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e7786e057c384cd08f74846d9463fe062025-08-20T02:21:10ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/768938768938The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa CellsYu Wu0Xianjing Hu1Liyan Song2Jianhua Zhu3Rongmin Yu4Biotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, ChinaDepartment of Pharmacology, Jinan University, Guangzhou 510632, ChinaDepartment of Pharmacology, Jinan University, Guangzhou 510632, ChinaBiotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, ChinaBiotechnological Institute of Chinese Materia Medica, Jinan University, Guangzhou 510632, ChinaInflammation is known to be closely associated with the development of cancer. The study was launched in human cervical cancer HeLa cells to investigate the antitumor and anti-inflammatory effects of P2, a marine polypeptide fraction from an important fishery resource Arca subcrenata. The basic research showed that P2 could suppress the production of nitric oxide in LPS-induced RAW264.7 macrophage cells as well as the secretion of inflammatory cytokines IL-6 and TNF-α in human cervical cancer HeLa cells. For the molecular mechanisms, P2 was shown to downregulate the gene expression of proinflammatory cytokines IL-6 and IL-8 and to inhibit the COX-2 and iNOS-related pathways in HeLa cells. In consequence, P2 might inhibit tumor development by blocking the interaction between tumor microenvironment and proinflammatory mediators. All findings indicate that P2 possesses the potential to be developed as a novel agent for cancer therapy.http://dx.doi.org/10.1155/2014/768938 |
| spellingShingle | Yu Wu Xianjing Hu Liyan Song Jianhua Zhu Rongmin Yu The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells The Scientific World Journal |
| title | The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells |
| title_full | The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells |
| title_fullStr | The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells |
| title_full_unstemmed | The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells |
| title_short | The Inhibitory Effect of a Novel Polypeptide Fraction from Arca subcrenata on Cancer-Related Inflammation in Human Cervical Cancer HeLa Cells |
| title_sort | inhibitory effect of a novel polypeptide fraction from arca subcrenata on cancer related inflammation in human cervical cancer hela cells |
| url | http://dx.doi.org/10.1155/2014/768938 |
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