Inhibition of IGF-1Rα affects the differentiation fate of rat optic cup-derived retinal stem cells to retinal ganglion cells in vitro

Inhibition of IGF-1Rα affects the differentiation fate of rat optic cup-derived retinal stem cells to retinal ganglion cells in vitro

AIM: To explore the impact of insulin-like growth factor-1 receptor α (IGF-1Rα) on the differentiation fate of optic-cup-derived retinal stem cells (OC-RSCs) into retinal ganglion cells (RGCs) in vitro. METHODS: OC-RSCs were isolated from optic cups of rats on embryonic day 12.5, and high-purity OC-...

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Bibliographic Details
Main Authors:	Qi-You Li, Xiao-Ling Tan, Hai-Wei Xu, Yu-Xiao Zeng, Xiao-Yong Huang
Format:	Article
Language:	English
Published:	Press of International Journal of Ophthalmology (IJO PRESS) 2025-04-01
Series:	International Journal of Ophthalmology
Subjects:	insulin-like growth factor-1 receptor α retinal ganglion cell rat optic cup retinal stem cells differentiation fate
Online Access:	http://ies.ijo.cn/en_publish/2025/4/20250403.pdf
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