A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?
In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2017/6947034 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558487906811904 |
|---|---|
| author | Vasiliki D. Papakonstantinou Nefeli Lagopati Effie C. Tsilibary Constantinos A. Demopoulos Athanassios I. Philippopoulos |
| author_facet | Vasiliki D. Papakonstantinou Nefeli Lagopati Effie C. Tsilibary Constantinos A. Demopoulos Athanassios I. Philippopoulos |
| author_sort | Vasiliki D. Papakonstantinou |
| collection | DOAJ |
| description | In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors. |
| format | Article |
| id | doaj-art-e7716db236a741da8fe236441704ffcf |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-e7716db236a741da8fe236441704ffcf2025-02-03T01:32:15ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2017-01-01201710.1155/2017/69470346947034A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?Vasiliki D. Papakonstantinou0Nefeli Lagopati1Effie C. Tsilibary2Constantinos A. Demopoulos3Athanassios I. Philippopoulos4Laboratory of Biochemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, GreeceInstitute of Biosciences & Applications, NCSR Demokritos, 15310 Agia Paraskevi, GreeceInstitute of Biosciences & Applications, NCSR Demokritos, 15310 Agia Paraskevi, GreeceLaboratory of Biochemistry, Faculty of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, GreeceLaboratory of Inorganic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, GreeceIn this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminary structure-activity relationships for the different classes of metal-based inhibitors.http://dx.doi.org/10.1155/2017/6947034 |
| spellingShingle | Vasiliki D. Papakonstantinou Nefeli Lagopati Effie C. Tsilibary Constantinos A. Demopoulos Athanassios I. Philippopoulos A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? Bioinorganic Chemistry and Applications |
| title | A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? |
| title_full | A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? |
| title_fullStr | A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? |
| title_full_unstemmed | A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? |
| title_short | A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties? |
| title_sort | review on platelet activating factor inhibitors could a new class of potent metal based anti inflammatory drugs induce anticancer properties |
| url | http://dx.doi.org/10.1155/2017/6947034 |
| work_keys_str_mv | AT vasilikidpapakonstantinou areviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT nefelilagopati areviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT effiectsilibary areviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT constantinosademopoulos areviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT athanassiosiphilippopoulos areviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT vasilikidpapakonstantinou reviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT nefelilagopati reviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT effiectsilibary reviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT constantinosademopoulos reviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties AT athanassiosiphilippopoulos reviewonplateletactivatingfactorinhibitorscouldanewclassofpotentmetalbasedantiinflammatorydrugsinduceanticancerproperties |