Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases
This review explores recent advancements in inhaled nanoparticle formulations and inhalation devices, with a focus on various types of nanoparticles used for inhalation to treat inflammatory lung diseases and the types of devices used in their delivery. Medical nebulizers have been found to be the m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/7/893 |
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| author | Doaa Elsayed Mahmoud Seyedeh Hanieh Hosseini Hassaan Anwer Rathore Alaaldin M. Alkilany Andreas Heise Abdelbary Elhissi |
| author_facet | Doaa Elsayed Mahmoud Seyedeh Hanieh Hosseini Hassaan Anwer Rathore Alaaldin M. Alkilany Andreas Heise Abdelbary Elhissi |
| author_sort | Doaa Elsayed Mahmoud |
| collection | DOAJ |
| description | This review explores recent advancements in inhaled nanoparticle formulations and inhalation devices, with a focus on various types of nanoparticles used for inhalation to treat inflammatory lung diseases and the types of devices used in their delivery. Medical nebulizers have been found to be the most appropriate type of inhalation devices for the pulmonary delivery of nanoparticles, since formulations can be prepared using straightforward techniques, with no need for liquefied propellants as in the case of pressurized metered dose inhalers (pMDIs), or complicated preparation procedures as in the case of dry powder inhalers (DPIs). We demonstrated examples of how formulations should be designed considering the operation mechanism of nebulizers, and how an interplay of factors can affect the aerosol characteristics of nanoparticle formulations. Overall, nanoparticle-based formulations offer promising potential for the treatment of inflammatory lung diseases due to their unique physicochemical properties and ability to provide localized drug delivery in the lung following inhalation. |
| format | Article |
| id | doaj-art-e76c445c3b524730b17d859b2a694cea |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-e76c445c3b524730b17d859b2a694cea2025-08-20T03:32:15ZengMDPI AGPharmaceutics1999-49232025-07-0117789310.3390/pharmaceutics17070893Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung DiseasesDoaa Elsayed Mahmoud0Seyedeh Hanieh Hosseini1Hassaan Anwer Rathore2Alaaldin M. Alkilany3Andreas Heise4Abdelbary Elhissi5Department of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha 2713, QatarDepartment of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha 2713, QatarDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha 2713, QatarDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha 2713, QatarDepartment of Chemistry, Royal College of Surgeons in Ireland, University of Medicine and Health Sciences, D02 YN77 Dublin, IrelandDepartment of Pharmaceutical Sciences, College of Pharmacy, QU Health, Qatar University, Doha 2713, QatarThis review explores recent advancements in inhaled nanoparticle formulations and inhalation devices, with a focus on various types of nanoparticles used for inhalation to treat inflammatory lung diseases and the types of devices used in their delivery. Medical nebulizers have been found to be the most appropriate type of inhalation devices for the pulmonary delivery of nanoparticles, since formulations can be prepared using straightforward techniques, with no need for liquefied propellants as in the case of pressurized metered dose inhalers (pMDIs), or complicated preparation procedures as in the case of dry powder inhalers (DPIs). We demonstrated examples of how formulations should be designed considering the operation mechanism of nebulizers, and how an interplay of factors can affect the aerosol characteristics of nanoparticle formulations. Overall, nanoparticle-based formulations offer promising potential for the treatment of inflammatory lung diseases due to their unique physicochemical properties and ability to provide localized drug delivery in the lung following inhalation.https://www.mdpi.com/1999-4923/17/7/893nanoparticlesinhalation devicesdrug deliveryinflammatory lung disorders |
| spellingShingle | Doaa Elsayed Mahmoud Seyedeh Hanieh Hosseini Hassaan Anwer Rathore Alaaldin M. Alkilany Andreas Heise Abdelbary Elhissi Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases Pharmaceutics nanoparticles inhalation devices drug delivery inflammatory lung disorders |
| title | Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases |
| title_full | Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases |
| title_fullStr | Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases |
| title_full_unstemmed | Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases |
| title_short | Inhalable Nanotechnology-Based Drug Delivery Systems for the Treatment of Inflammatory Lung Diseases |
| title_sort | inhalable nanotechnology based drug delivery systems for the treatment of inflammatory lung diseases |
| topic | nanoparticles inhalation devices drug delivery inflammatory lung disorders |
| url | https://www.mdpi.com/1999-4923/17/7/893 |
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