A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome
Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction if it is not timely diagnosed and treated. This happens probably following a cascade of immune reactions after the administration of the drug ultimately leading to multiorgan failure an...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2020/8837607 |
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| author | S. Vithana M. H. A. D. De Silva G. P. Hewawitharana |
| author_facet | S. Vithana M. H. A. D. De Silva G. P. Hewawitharana |
| author_sort | S. Vithana |
| collection | DOAJ |
| description | Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction if it is not timely diagnosed and treated. This happens probably following a cascade of immune reactions after the administration of the drug ultimately leading to multiorgan failure and death. Several groups of drugs have been identified as potential aetiologies but the commonest one identified is antiepileptic drugs. The clinical features of DRESS syndrome usually appear several weeks after commencing the offending drug. Initially, fever lymphadenopathy and rash appear followed by hepatitis. Rash is the most prominent feature, and it is a generalized erythematous nonblanching maculopapular rash without the involvement of the mucus membranes or eyes. The rash desquamated over the following days and changed it’s context to an exfoliative dermatitis. We report a case of a 10-year-old boy who is one of the twins born to nonconsanguineous parents at 34 weeks of gestation. |
| format | Article |
| id | doaj-art-e76a0b415e1f4f3f886aaea58d512628 |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-e76a0b415e1f4f3f886aaea58d5126282025-08-20T03:26:10ZengWileyCase Reports in Pediatrics2090-68032090-68112020-01-01202010.1155/2020/88376078837607A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS SyndromeS. Vithana0M. H. A. D. De Silva1G. P. Hewawitharana2Lady Ridgeway Hospital for Children, Colombo, Sri LankaDeparment of Paedaitrics, Faculty of Medicine, University of Ruhuna, Galle, Sri LankaTeaching Hospital Karapitiya, Galle, Sri LankaDrug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening adverse drug reaction if it is not timely diagnosed and treated. This happens probably following a cascade of immune reactions after the administration of the drug ultimately leading to multiorgan failure and death. Several groups of drugs have been identified as potential aetiologies but the commonest one identified is antiepileptic drugs. The clinical features of DRESS syndrome usually appear several weeks after commencing the offending drug. Initially, fever lymphadenopathy and rash appear followed by hepatitis. Rash is the most prominent feature, and it is a generalized erythematous nonblanching maculopapular rash without the involvement of the mucus membranes or eyes. The rash desquamated over the following days and changed it’s context to an exfoliative dermatitis. We report a case of a 10-year-old boy who is one of the twins born to nonconsanguineous parents at 34 weeks of gestation.http://dx.doi.org/10.1155/2020/8837607 |
| spellingShingle | S. Vithana M. H. A. D. De Silva G. P. Hewawitharana A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome Case Reports in Pediatrics |
| title | A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome |
| title_full | A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome |
| title_fullStr | A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome |
| title_full_unstemmed | A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome |
| title_short | A Ten-Year-Old Boy with Antiepileptic Drugs-Induced DRESS Syndrome |
| title_sort | ten year old boy with antiepileptic drugs induced dress syndrome |
| url | http://dx.doi.org/10.1155/2020/8837607 |
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