Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China
Background and Objective. Haemophilus influenzae (HI) is a common cause of community-acquired pneumonia in children. In many countries, HI strains are increasingly resistant to ampicillin and other commonly prescribed antibiotics, posing a challenge for effective clinical treatment. This study was u...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Canadian Journal of Infectious Diseases and Medical Microbiology |
| Online Access: | http://dx.doi.org/10.1155/2019/6456321 |
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| author | Hong-Jiao Wang Chuan-Qing Wang Chun-Zhen Hua Hui Yu Ting Zhang Hong Zhang Shi-Fu Wang Ai-Wei Lin Qing Cao Wei-Chun Huang Hui-Ling Deng Shan-Cheng Cao Xue-jun Chen |
| author_facet | Hong-Jiao Wang Chuan-Qing Wang Chun-Zhen Hua Hui Yu Ting Zhang Hong Zhang Shi-Fu Wang Ai-Wei Lin Qing Cao Wei-Chun Huang Hui-Ling Deng Shan-Cheng Cao Xue-jun Chen |
| author_sort | Hong-Jiao Wang |
| collection | DOAJ |
| description | Background and Objective. Haemophilus influenzae (HI) is a common cause of community-acquired pneumonia in children. In many countries, HI strains are increasingly resistant to ampicillin and other commonly prescribed antibiotics, posing a challenge for effective clinical treatment. This study was undertaken to determine the antibiotic resistance profiles of HI isolates from Chinese children and to provide guidelines for clinical treatment. Methods. Our Infectious Disease Surveillance of Pediatrics (ISPED) collaboration group includes six children’s hospitals in different regions of China. The same protocols and guidelines were used by all collaborators for the culture and identification of HI. The Kirby–Bauer method was used to test antibiotic susceptibility, and a cefinase disc was used to detect β-lactamase activity. Results. We isolated 2073 HI strains in 2016: 83.9% from the respiratory tract, 11.1% from vaginal secretions, and 0.5% from blood. Patients with respiratory isolates were significantly younger than nonrespiratory patients (P<0.001). Of all 2073 strains, 50.3% were positive for β-lactamase and 58.1% were resistant to ampicillin; 9.3% were β-lactamase-negative and ampicillin-resistant. The resistance rates of the HI isolates to trimethoprim-sulfamethoxazole, azithromycin, cefuroxime, ampicillin-sulbactam, cefotaxime, and meropenem were 71.1%, 32.0%, 31.2%, 17.6%, 5.9%, and 0.2%, respectively. Conclusions. More than half of the HI strains isolated from Chinese children were resistant to ampicillin, primarily due to the production of β-lactamase. Cefotaxime and other third-generation cephalosporins could be the first choice for the treatment of ampicillin-resistant HI infections. |
| format | Article |
| id | doaj-art-e76937695ae1466d8b764c592b6ea427 |
| institution | Kabale University |
| issn | 1712-9532 1918-1493 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases and Medical Microbiology |
| spelling | doaj-art-e76937695ae1466d8b764c592b6ea4272025-08-20T03:26:10ZengWileyCanadian Journal of Infectious Diseases and Medical Microbiology1712-95321918-14932019-01-01201910.1155/2019/64563216456321Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in ChinaHong-Jiao Wang0Chuan-Qing Wang1Chun-Zhen Hua2Hui Yu3Ting Zhang4Hong Zhang5Shi-Fu Wang6Ai-Wei Lin7Qing Cao8Wei-Chun Huang9Hui-Ling Deng10Shan-Cheng Cao11Xue-jun Chen12Division of Infectious Diseases, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDepartment of Clinical Laboratory, Children’s Hospital of Fudan University, Shanghai 201102, ChinaDivision of Infectious Diseases, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaDivision of Infectious Diseases, Children’s Hospital of Fudan University, Shanghai 201102, ChinaDivision of Infectious Diseases, Children’s Hospital of Shanghai Jiaotong University, Shanghai 200240, ChinaDepartment of Clinical Laboratory, Children’s Hospital of Shanghai Jiaotong University, Shanghai 200240, ChinaDepartment of Clinical Laboratory, Qilu Children’s Hospital of Shandong University, Jinan 250022, ChinaDivision of Infectious Diseases, Qilu Children’s Hospital of Shandong University, Jinan 250022, ChinaDivision of Infectious Diseases, Shanghai Children’s Medical Center, Shanghai 200127, ChinaDepartment of Clinical Laboratory, Shanghai Children’s Medical Center, Shanghai 200127, ChinaDepartment of Clinical Laboratory, Xi’an Children’s Hospital, Xi’an 710043, ChinaDivision of Infectious Diseases, Xi’an Children’s Hospital, Xi’an 710043, ChinaDepartment of Clinical Laboratory, The Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310003, ChinaBackground and Objective. Haemophilus influenzae (HI) is a common cause of community-acquired pneumonia in children. In many countries, HI strains are increasingly resistant to ampicillin and other commonly prescribed antibiotics, posing a challenge for effective clinical treatment. This study was undertaken to determine the antibiotic resistance profiles of HI isolates from Chinese children and to provide guidelines for clinical treatment. Methods. Our Infectious Disease Surveillance of Pediatrics (ISPED) collaboration group includes six children’s hospitals in different regions of China. The same protocols and guidelines were used by all collaborators for the culture and identification of HI. The Kirby–Bauer method was used to test antibiotic susceptibility, and a cefinase disc was used to detect β-lactamase activity. Results. We isolated 2073 HI strains in 2016: 83.9% from the respiratory tract, 11.1% from vaginal secretions, and 0.5% from blood. Patients with respiratory isolates were significantly younger than nonrespiratory patients (P<0.001). Of all 2073 strains, 50.3% were positive for β-lactamase and 58.1% were resistant to ampicillin; 9.3% were β-lactamase-negative and ampicillin-resistant. The resistance rates of the HI isolates to trimethoprim-sulfamethoxazole, azithromycin, cefuroxime, ampicillin-sulbactam, cefotaxime, and meropenem were 71.1%, 32.0%, 31.2%, 17.6%, 5.9%, and 0.2%, respectively. Conclusions. More than half of the HI strains isolated from Chinese children were resistant to ampicillin, primarily due to the production of β-lactamase. Cefotaxime and other third-generation cephalosporins could be the first choice for the treatment of ampicillin-resistant HI infections.http://dx.doi.org/10.1155/2019/6456321 |
| spellingShingle | Hong-Jiao Wang Chuan-Qing Wang Chun-Zhen Hua Hui Yu Ting Zhang Hong Zhang Shi-Fu Wang Ai-Wei Lin Qing Cao Wei-Chun Huang Hui-Ling Deng Shan-Cheng Cao Xue-jun Chen Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China Canadian Journal of Infectious Diseases and Medical Microbiology |
| title | Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China |
| title_full | Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China |
| title_fullStr | Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China |
| title_full_unstemmed | Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China |
| title_short | Antibiotic Resistance Profiles of Haemophilus influenzae Isolates from Children in 2016: A Multicenter Study in China |
| title_sort | antibiotic resistance profiles of haemophilus influenzae isolates from children in 2016 a multicenter study in china |
| url | http://dx.doi.org/10.1155/2019/6456321 |
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