The natural preferred retinal locus in patients with macular disease
Abstract This study aimed to explore the characteristics of the natural Preferred Retinal Locus (PRL) in eyes with different macular lesions. In this retrospective study, 37 patients (39 eyes) suffered from macular diseases (MD) were included, and the following data were collected: best corrected vi...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88421-6 |
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| author | Shengnan Li Danjie Li Li Wang Huimin Lin Jinglin Zhang |
| author_facet | Shengnan Li Danjie Li Li Wang Huimin Lin Jinglin Zhang |
| author_sort | Shengnan Li |
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| description | Abstract This study aimed to explore the characteristics of the natural Preferred Retinal Locus (PRL) in eyes with different macular lesions. In this retrospective study, 37 patients (39 eyes) suffered from macular diseases (MD) were included, and the following data were collected: best corrected visual acuity (BCVA), mean sensitivity of macular area in 10 deg diameter (MS), bivariate contour ellipse area (63% BCEA and 95% BCEA), fixation stability, and fundus images and sectional images of the fovea. A natural PRL did not develop in 10 eyes with macular disease. A total of 29 eyes developed natural PRLs: 42% developed superior PRLs, 17% developed temporal PRLs, 24% developed nasal PRLs, 7% developed multiple PRLs, 10% developed PRLs inside the “dark area”, and there were no independent inferior PRLs. In the inside group, the mean MS was significantly lower than that of the other four groups; and the variations in log BCEA were greater in group M compared with group S (P < 0.01), group T (P < 0.01) and group N (P < 0.01), but there were no obvious differences among group S, group T and group N. A natural PRL tends to be more localized in the upper retina, possibly to preserve the lower visual field, followed by nasal and temporal, and rarely localized in the lower retina, and multiple scattered PRLs can be formed when the lesion was widespread. If the function of the fovea exists, even if the lesion in the macular area is clear, the patient still uses the fovea for central fixation and does not form PRL. |
| format | Article |
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| institution | Kabale University |
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| language | English |
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| spelling | doaj-art-e7682eb230424998b17b3877fcae01002025-08-20T03:42:57ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-88421-6The natural preferred retinal locus in patients with macular diseaseShengnan Li0Danjie Li1Li Wang2Huimin Lin3Jinglin Zhang4Sichuan Eye Hospital, AIER Eye Hospital GroupSichuan Eye Hospital, AIER Eye Hospital GroupSichuan Eye Hospital, AIER Eye Hospital GroupGuangzhou Aier Eye Hospital, Jinan UniversityDepartment of Ophthalmology, The First Affiliated Hospital of Jinan UniversityAbstract This study aimed to explore the characteristics of the natural Preferred Retinal Locus (PRL) in eyes with different macular lesions. In this retrospective study, 37 patients (39 eyes) suffered from macular diseases (MD) were included, and the following data were collected: best corrected visual acuity (BCVA), mean sensitivity of macular area in 10 deg diameter (MS), bivariate contour ellipse area (63% BCEA and 95% BCEA), fixation stability, and fundus images and sectional images of the fovea. A natural PRL did not develop in 10 eyes with macular disease. A total of 29 eyes developed natural PRLs: 42% developed superior PRLs, 17% developed temporal PRLs, 24% developed nasal PRLs, 7% developed multiple PRLs, 10% developed PRLs inside the “dark area”, and there were no independent inferior PRLs. In the inside group, the mean MS was significantly lower than that of the other four groups; and the variations in log BCEA were greater in group M compared with group S (P < 0.01), group T (P < 0.01) and group N (P < 0.01), but there were no obvious differences among group S, group T and group N. A natural PRL tends to be more localized in the upper retina, possibly to preserve the lower visual field, followed by nasal and temporal, and rarely localized in the lower retina, and multiple scattered PRLs can be formed when the lesion was widespread. If the function of the fovea exists, even if the lesion in the macular area is clear, the patient still uses the fovea for central fixation and does not form PRL.https://doi.org/10.1038/s41598-025-88421-6Preferred retinal locusBiofeedback trainingChoroidal neovascularizationMacular holeFovea dysfunctionCentral vision loss |
| spellingShingle | Shengnan Li Danjie Li Li Wang Huimin Lin Jinglin Zhang The natural preferred retinal locus in patients with macular disease Scientific Reports Preferred retinal locus Biofeedback training Choroidal neovascularization Macular hole Fovea dysfunction Central vision loss |
| title | The natural preferred retinal locus in patients with macular disease |
| title_full | The natural preferred retinal locus in patients with macular disease |
| title_fullStr | The natural preferred retinal locus in patients with macular disease |
| title_full_unstemmed | The natural preferred retinal locus in patients with macular disease |
| title_short | The natural preferred retinal locus in patients with macular disease |
| title_sort | natural preferred retinal locus in patients with macular disease |
| topic | Preferred retinal locus Biofeedback training Choroidal neovascularization Macular hole Fovea dysfunction Central vision loss |
| url | https://doi.org/10.1038/s41598-025-88421-6 |
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