Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study)
Introduction: Low energy diets (LEDs) may slow disease progression; however, their effects are under researched in chronic kidney disease (CKD). This study evaluated the safety and feasibility of an LED weight management program in adults with obesity and CKD. Methods: This multicenter 6-month rando...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Kidney International Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468024925002451 |
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| author | Marguerite M. Conley Hannah L. Mayr Kirsten S. Hepburn Justin J. Holland David W. Mudge Tammy J. Tonges Richard S. Modderman Sally A. Gerzina David W. Johnson Andrea K. Viecelli Helen L. MacLaughlin |
| author_facet | Marguerite M. Conley Hannah L. Mayr Kirsten S. Hepburn Justin J. Holland David W. Mudge Tammy J. Tonges Richard S. Modderman Sally A. Gerzina David W. Johnson Andrea K. Viecelli Helen L. MacLaughlin |
| author_sort | Marguerite M. Conley |
| collection | DOAJ |
| description | Introduction: Low energy diets (LEDs) may slow disease progression; however, their effects are under researched in chronic kidney disease (CKD). This study evaluated the safety and feasibility of an LED weight management program in adults with obesity and CKD. Methods: This multicenter 6-month randomized controlled trial (RCT) involved adults with CKD Kidney Disease: Improving Global Outcomes stages G1 to G3b, obesity, and proteinuria, randomized 1:1 into 2 groups. The LED group followed a 3-month 800 to 900 kcal/d LED, with dietitian support, then a 3-month weight maintenance phase with exercise and healthy eating support. The usual care (UC) group received standard clinic weight loss support. Primary outcomes were safety (serious adverse events [SAEs]) and feasibility (≥2 of recruitment rate ≥ 25%, LED group retention rate ≥ 75%, and ≥ 30% of LED group achieving ≥ 10 kg weight loss at 3 months). Secondary outcomes included changes in anthropometry, clinical measures, patient-reported outcomes, and participant experiences. Results: Forty-nine participants (median age 51 years, 57% male) consented. SAEs were low and comparable as follows: 2 in the LED group (hypoglycemia and acute kidney injury) and 2 in the UC group (hypoglycemia), all requiring hospitalization. Feasibility was met for recruitment (46%) and weight loss (46% achieved ≥ 10 kg loss) but not for retention (67% retained). At 6 months, median (IQR) weight change was −9.0 kg (−12 to −7) in the LED group and 0 kg (−4 to 2) in the UC group (P < 0.001). Conclusion: LEDs under professional guidance are safe and feasible for weight loss in adults with obesity and CKD Kidney Disease: Improving Global Outcomes stages G1 to G3b. A definitive RCT to assess their effects on clinical outcomes and CKD progression is warranted. |
| format | Article |
| id | doaj-art-e7665d779aea41cfb36a6688697db158 |
| institution | Kabale University |
| issn | 2468-0249 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj-art-e7665d779aea41cfb36a6688697db1582025-08-20T03:24:16ZengElsevierKidney International Reports2468-02492025-07-011072153216410.1016/j.ekir.2025.04.021Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study)Marguerite M. Conley0Hannah L. Mayr1Kirsten S. Hepburn2Justin J. Holland3David W. Mudge4Tammy J. Tonges5Richard S. Modderman6Sally A. Gerzina7David W. Johnson8Andrea K. Viecelli9Helen L. MacLaughlin10School of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia; Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Department of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Correspondence: Marguerite M. Conley, Department of Nutrition and Dietetics, Princess Alexandra Hospital, 199 Ipswich Rd, Woolloongabba, Queensland 4102 Queensland, Australia.Department of Nutrition and Dietetics, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Centre for Functioning and Health Research, Metro South Hospital and Health Service, Brisbane, Queensland, AustraliaKidney Health Service, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, AustraliaSchool of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, AustraliaDepartment of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Australasian Kidney Trials Network, University of Queensland, Brisbane, Queensland, Australia; Redland Hospital, Brisbane, Queensland, AustraliaConsumer Co-researcher, Brisbane, Queensland, AustraliaFlinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park South Australia, Australia; Department of Physiotherapy, Sunshine Coast University Hospital, Birtinya, Queensland, AustraliaDepartment of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Queensland, AustraliaDepartment of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Australasian Kidney Trials Network, University of Queensland, Brisbane, Queensland, AustraliaDepartment of Kidney and Transplant Services, Princess Alexandra Hospital, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Australasian Kidney Trials Network, University of Queensland, Brisbane, Queensland, AustraliaSchool of Exercise and Nutrition Sciences, Queensland University of Technology, Brisbane, Queensland, Australia; Centre for Functioning and Health Research, Metro South Hospital and Health Service, Brisbane, Queensland, Australia; Nutrition Research Collaborative, Dietetics and Foodservices, Royal Brisbane and Women’s Hospital, Brisbane, Queensland, AustraliaIntroduction: Low energy diets (LEDs) may slow disease progression; however, their effects are under researched in chronic kidney disease (CKD). This study evaluated the safety and feasibility of an LED weight management program in adults with obesity and CKD. Methods: This multicenter 6-month randomized controlled trial (RCT) involved adults with CKD Kidney Disease: Improving Global Outcomes stages G1 to G3b, obesity, and proteinuria, randomized 1:1 into 2 groups. The LED group followed a 3-month 800 to 900 kcal/d LED, with dietitian support, then a 3-month weight maintenance phase with exercise and healthy eating support. The usual care (UC) group received standard clinic weight loss support. Primary outcomes were safety (serious adverse events [SAEs]) and feasibility (≥2 of recruitment rate ≥ 25%, LED group retention rate ≥ 75%, and ≥ 30% of LED group achieving ≥ 10 kg weight loss at 3 months). Secondary outcomes included changes in anthropometry, clinical measures, patient-reported outcomes, and participant experiences. Results: Forty-nine participants (median age 51 years, 57% male) consented. SAEs were low and comparable as follows: 2 in the LED group (hypoglycemia and acute kidney injury) and 2 in the UC group (hypoglycemia), all requiring hospitalization. Feasibility was met for recruitment (46%) and weight loss (46% achieved ≥ 10 kg loss) but not for retention (67% retained). At 6 months, median (IQR) weight change was −9.0 kg (−12 to −7) in the LED group and 0 kg (−4 to 2) in the UC group (P < 0.001). Conclusion: LEDs under professional guidance are safe and feasible for weight loss in adults with obesity and CKD Kidney Disease: Improving Global Outcomes stages G1 to G3b. A definitive RCT to assess their effects on clinical outcomes and CKD progression is warranted.http://www.sciencedirect.com/science/article/pii/S2468024925002451chronic kidney diseaselow energy dietmeal replacementobesityweight lossweight management |
| spellingShingle | Marguerite M. Conley Hannah L. Mayr Kirsten S. Hepburn Justin J. Holland David W. Mudge Tammy J. Tonges Richard S. Modderman Sally A. Gerzina David W. Johnson Andrea K. Viecelli Helen L. MacLaughlin Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study) Kidney International Reports chronic kidney disease low energy diet meal replacement obesity weight loss weight management |
| title | Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study) |
| title_full | Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study) |
| title_fullStr | Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study) |
| title_full_unstemmed | Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study) |
| title_short | Low Energy Diets for Obesity and CKD (SLOW-CKD Randomized Feasibility Study) |
| title_sort | low energy diets for obesity and ckd slow ckd randomized feasibility study |
| topic | chronic kidney disease low energy diet meal replacement obesity weight loss weight management |
| url | http://www.sciencedirect.com/science/article/pii/S2468024925002451 |
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