Chronic urticaria and vitamin D supplementations: a systematic review
Abstract Background Chronic urticaria (CU), especially chronic spontaneous urticaria (CSU), is a long-term inflammatory skin condition marked by wheals and/or angioedema lasting over six weeks. Emerging evidence suggests a link between vitamin D deficiency and immune dysregulation associated with CU...
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| Language: | English |
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BMC
2025-07-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02852-5 |
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| author | Ayesha Siddiqui Aruna Bai Haresh Kumar Yash Roop Mandhwani Anjali Bai Priya Bai Neha kumar F. N. U. Muskan Sumaiya Jatoi Zulfiqar Ali Abida Parveen |
| author_facet | Ayesha Siddiqui Aruna Bai Haresh Kumar Yash Roop Mandhwani Anjali Bai Priya Bai Neha kumar F. N. U. Muskan Sumaiya Jatoi Zulfiqar Ali Abida Parveen |
| author_sort | Ayesha Siddiqui |
| collection | DOAJ |
| description | Abstract Background Chronic urticaria (CU), especially chronic spontaneous urticaria (CSU), is a long-term inflammatory skin condition marked by wheals and/or angioedema lasting over six weeks. Emerging evidence suggests a link between vitamin D deficiency and immune dysregulation associated with CU. Given vitamin D’s immunomodulatory and anti-inflammatory effects, this review explores the therapeutic potential of vitamin D supplementation in CU management. Methods A systematic review was conducted in accordance with PRISMA guidelines Electronic databases (PubMed, Scopus, Web of Science, and Google Scholar) were searched using relevant keywords. Studies included were randomized controlled trials (RCTs), case–control, and observational studies assessing serum vitamin D levels or supplementation in patients with CU. Data extraction and bias assessment were independently conducted using standardized tools: the Cochrane Risk of Bias Tool and the Newcastle–Ottawa Scale. Results Eleven studies involving 1,491 participants were included. Most studies demonstrated significantly lower serum 25(OH)D levels in patients with CU compared to healthy controls. Vitamin D supplementation, particularly in individuals with a deficiency, was associated with reductions in urticaria activity scores, symptom severity, and improved quality of life. High-dose regimens (e.g., 4,000 IU/day or 60,000 IU/week) appeared more effective. However, results varied due to heterogeneity in study design, dosage, and patient characteristics. Conclusion Vitamin D supplementation may serve as a safe, accessible adjunct to standard CU treatment, particularly for those with confirmed deficiency. While evidence suggests potential benefits, further high-quality RCTs are needed to establish causality, optimal dosing, and long-term efficacy. |
| format | Article |
| id | doaj-art-e7644b34c87542288be93f89846f1334 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-e7644b34c87542288be93f89846f13342025-08-20T03:45:57ZengBMCEuropean Journal of Medical Research2047-783X2025-07-013011910.1186/s40001-025-02852-5Chronic urticaria and vitamin D supplementations: a systematic reviewAyesha Siddiqui0Aruna Bai1Haresh Kumar2Yash Roop Mandhwani3Anjali Bai4Priya Bai5Neha kumar6F. N. U. Muskan7Sumaiya Jatoi8Zulfiqar Ali9Abida Parveen10Department of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalDepartment of Medicine, Ibn E Seena HospitalAbstract Background Chronic urticaria (CU), especially chronic spontaneous urticaria (CSU), is a long-term inflammatory skin condition marked by wheals and/or angioedema lasting over six weeks. Emerging evidence suggests a link between vitamin D deficiency and immune dysregulation associated with CU. Given vitamin D’s immunomodulatory and anti-inflammatory effects, this review explores the therapeutic potential of vitamin D supplementation in CU management. Methods A systematic review was conducted in accordance with PRISMA guidelines Electronic databases (PubMed, Scopus, Web of Science, and Google Scholar) were searched using relevant keywords. Studies included were randomized controlled trials (RCTs), case–control, and observational studies assessing serum vitamin D levels or supplementation in patients with CU. Data extraction and bias assessment were independently conducted using standardized tools: the Cochrane Risk of Bias Tool and the Newcastle–Ottawa Scale. Results Eleven studies involving 1,491 participants were included. Most studies demonstrated significantly lower serum 25(OH)D levels in patients with CU compared to healthy controls. Vitamin D supplementation, particularly in individuals with a deficiency, was associated with reductions in urticaria activity scores, symptom severity, and improved quality of life. High-dose regimens (e.g., 4,000 IU/day or 60,000 IU/week) appeared more effective. However, results varied due to heterogeneity in study design, dosage, and patient characteristics. Conclusion Vitamin D supplementation may serve as a safe, accessible adjunct to standard CU treatment, particularly for those with confirmed deficiency. While evidence suggests potential benefits, further high-quality RCTs are needed to establish causality, optimal dosing, and long-term efficacy.https://doi.org/10.1186/s40001-025-02852-5Chronic urticarialChronic spontaneous urticarialVitamin DVitamin D supplementation25(OH)DImmunomodulation |
| spellingShingle | Ayesha Siddiqui Aruna Bai Haresh Kumar Yash Roop Mandhwani Anjali Bai Priya Bai Neha kumar F. N. U. Muskan Sumaiya Jatoi Zulfiqar Ali Abida Parveen Chronic urticaria and vitamin D supplementations: a systematic review European Journal of Medical Research Chronic urticarial Chronic spontaneous urticarial Vitamin D Vitamin D supplementation 25(OH)D Immunomodulation |
| title | Chronic urticaria and vitamin D supplementations: a systematic review |
| title_full | Chronic urticaria and vitamin D supplementations: a systematic review |
| title_fullStr | Chronic urticaria and vitamin D supplementations: a systematic review |
| title_full_unstemmed | Chronic urticaria and vitamin D supplementations: a systematic review |
| title_short | Chronic urticaria and vitamin D supplementations: a systematic review |
| title_sort | chronic urticaria and vitamin d supplementations a systematic review |
| topic | Chronic urticarial Chronic spontaneous urticarial Vitamin D Vitamin D supplementation 25(OH)D Immunomodulation |
| url | https://doi.org/10.1186/s40001-025-02852-5 |
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