Study of Variation of <i>ACOX1</i> Gene Among Different Horse Breeds Maintained in Iran
The <i>ACOX1</i> gene is vital for fatty acid metabolism and is linked to environmental stress and physical exertion adaptation. The p.Asp237Ser variant (rs782885985) in <i>ACOX1</i> is associated with increased enzyme activity and reactive oxygen species (ROS) levels. This s...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
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| Series: | Animals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2615/14/24/3566 |
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| Summary: | The <i>ACOX1</i> gene is vital for fatty acid metabolism and is linked to environmental stress and physical exertion adaptation. The p.Asp237Ser variant (rs782885985) in <i>ACOX1</i> is associated with increased enzyme activity and reactive oxygen species (ROS) levels. This study examined the <i>ACOX1</i> polymorphism across six horse breeds in Iran: Arabian, Thoroughbred, KWPN, Caspian, Kurdish, and Turkmen. The goal was to identify differences in <i>ACOX1</i> genotype distribution, potentially serving as genetic markers under selection pressure related to breed-specific traits. In a sample of 324 horses, genomic DNA was analyzed using PCR-RFLP, revealing three genotypes (TT, TG, GG). The GG genotype was most common in Kurdish and Arabian horses (86% and 70%, respectively), while the TT genotype was prevalent in Turkmen (24%) and Thoroughbred horses (23%). The T allele’s frequency in Thoroughbred and Turkmen horses suggests that ACOX1 may be under selection pressure for phenotypic traits. Differences in genotype distribution were confirmed among breeds, with no sex-based association. The study concludes that <i>ACOX1</i> is a potential genetic marker for horse performance and adaptability, emphasizing the importance of genetic diversity in breeding programs. |
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| ISSN: | 2076-2615 |