The Histone Modifications of Neuronal Plasticity
Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dim...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6690523 |
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| _version_ | 1850167675431419904 |
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| author | Huixia Geng Hongyang Chen Haiying Wang Lai Wang |
| author_facet | Huixia Geng Hongyang Chen Haiying Wang Lai Wang |
| author_sort | Huixia Geng |
| collection | DOAJ |
| description | Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dimensional structure of chromosomes and affect gene expression. Therefore, the combination of different states of histone modifications modulates gene expression is called histone code. The formation of learning and memory is one of the most important mechanisms for animals to adapt to environmental changes. A large number of studies have shown that histone codes are involved in the formation and consolidation of learning and memory. Here, we review the most recent literature of histone modification in regulating neurogenesis, dendritic spine dynamic, synapse formation, and synaptic plasticity. |
| format | Article |
| id | doaj-art-e760be1588e94c6786aa8d8a08ee9943 |
| institution | OA Journals |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-e760be1588e94c6786aa8d8a08ee99432025-08-20T02:21:09ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66905236690523The Histone Modifications of Neuronal PlasticityHuixia Geng0Hongyang Chen1Haiying Wang2Lai Wang3Institute of Chronic Disease Risks Assessment, School of Nursing and Health Sciences, Henan University, Kaifeng, 475004 Henan Province, ChinaCollege of Life Science, Henan University, Kaifeng, 475004 Henan Province, ChinaCollege of Life Science, Henan University, Kaifeng, 475004 Henan Province, ChinaInstitute of Chronic Disease Risks Assessment, School of Nursing and Health Sciences, Henan University, Kaifeng, 475004 Henan Province, ChinaNucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dimensional structure of chromosomes and affect gene expression. Therefore, the combination of different states of histone modifications modulates gene expression is called histone code. The formation of learning and memory is one of the most important mechanisms for animals to adapt to environmental changes. A large number of studies have shown that histone codes are involved in the formation and consolidation of learning and memory. Here, we review the most recent literature of histone modification in regulating neurogenesis, dendritic spine dynamic, synapse formation, and synaptic plasticity.http://dx.doi.org/10.1155/2021/6690523 |
| spellingShingle | Huixia Geng Hongyang Chen Haiying Wang Lai Wang The Histone Modifications of Neuronal Plasticity Neural Plasticity |
| title | The Histone Modifications of Neuronal Plasticity |
| title_full | The Histone Modifications of Neuronal Plasticity |
| title_fullStr | The Histone Modifications of Neuronal Plasticity |
| title_full_unstemmed | The Histone Modifications of Neuronal Plasticity |
| title_short | The Histone Modifications of Neuronal Plasticity |
| title_sort | histone modifications of neuronal plasticity |
| url | http://dx.doi.org/10.1155/2021/6690523 |
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