Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda.
<h4>Objectives</h4>Most data on HPV and antiretroviral therapy (ART) come from high-resource countries with infrequent sampling for HPV pre- and post-ART initiation. Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0055383 |
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| author | Anne F Rositch Patti E Gravitt Aaron A R Tobian Kevin Newell Thomas C Quinn David Serwadda Paschal Ssebbowa Valerian Kiggundu Ronald H Gray Steven J Reynolds |
| author_facet | Anne F Rositch Patti E Gravitt Aaron A R Tobian Kevin Newell Thomas C Quinn David Serwadda Paschal Ssebbowa Valerian Kiggundu Ronald H Gray Steven J Reynolds |
| author_sort | Anne F Rositch |
| collection | DOAJ |
| description | <h4>Objectives</h4>Most data on HPV and antiretroviral therapy (ART) come from high-resource countries with infrequent sampling for HPV pre- and post-ART initiation. Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for 6 months both before and after initiation of ART in Rakai, Uganda.<h4>Methods</h4>Linear Array was used to detect 37 HPV genotypes in self-collected cervicovaginal swabs from 96 women who initiated ART. Random-effects log-binomial regression was used to compare the prevalence of HPV detection in the pre- and post-ART periods and determine other potential risk factors, including CD4 counts and HIV viral load.<h4>Results</h4>Nearly all women had detectable HPV in the 6 months preceding ART initiation (92%) and the cumulative prevalence remained high following initiation of therapy (90%). We found no effect of ART on monthly HPV DNA detection (prevalence ratio: 1.0; 95% confidence interval: 0.96, 1.08), regardless of immune reconstitution or HIV viral suppression. Older age and higher pre-ART CD4 counts were associated with a significantly lower risk of HPV DNA detection.<h4>Conclusions</h4>ART did not impact HPV detection within 6 months of therapy initiation, highlighting the importance of continued and consistent screening, even after ART-initiation and immune reconstitution. |
| format | Article |
| id | doaj-art-e75aa6fcf39c42699424a70934184078 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e75aa6fcf39c42699424a709341840782025-08-20T02:05:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5538310.1371/journal.pone.0055383Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda.Anne F RositchPatti E GravittAaron A R TobianKevin NewellThomas C QuinnDavid SerwaddaPaschal SsebbowaValerian KiggunduRonald H GraySteven J Reynolds<h4>Objectives</h4>Most data on HPV and antiretroviral therapy (ART) come from high-resource countries with infrequent sampling for HPV pre- and post-ART initiation. Therefore, we examined the frequency of cervical HPV DNA detection among HIV/HSV-2 co-infected women followed monthly for 6 months both before and after initiation of ART in Rakai, Uganda.<h4>Methods</h4>Linear Array was used to detect 37 HPV genotypes in self-collected cervicovaginal swabs from 96 women who initiated ART. Random-effects log-binomial regression was used to compare the prevalence of HPV detection in the pre- and post-ART periods and determine other potential risk factors, including CD4 counts and HIV viral load.<h4>Results</h4>Nearly all women had detectable HPV in the 6 months preceding ART initiation (92%) and the cumulative prevalence remained high following initiation of therapy (90%). We found no effect of ART on monthly HPV DNA detection (prevalence ratio: 1.0; 95% confidence interval: 0.96, 1.08), regardless of immune reconstitution or HIV viral suppression. Older age and higher pre-ART CD4 counts were associated with a significantly lower risk of HPV DNA detection.<h4>Conclusions</h4>ART did not impact HPV detection within 6 months of therapy initiation, highlighting the importance of continued and consistent screening, even after ART-initiation and immune reconstitution.https://doi.org/10.1371/journal.pone.0055383 |
| spellingShingle | Anne F Rositch Patti E Gravitt Aaron A R Tobian Kevin Newell Thomas C Quinn David Serwadda Paschal Ssebbowa Valerian Kiggundu Ronald H Gray Steven J Reynolds Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda. PLoS ONE |
| title | Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda. |
| title_full | Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda. |
| title_fullStr | Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda. |
| title_full_unstemmed | Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda. |
| title_short | Frequent detection of HPV before and after initiation of antiretroviral therapy among HIV/HSV-2 co-infected women in Uganda. |
| title_sort | frequent detection of hpv before and after initiation of antiretroviral therapy among hiv hsv 2 co infected women in uganda |
| url | https://doi.org/10.1371/journal.pone.0055383 |
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