Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence
Cellular senescence plays a very important role in organismal aging increasing with age and in age-related diseases (ARDs). This process involves physiological, structural, biochemical, and molecular changes of cells, leading to a characteristic trait referred to “senescence-associated secretory phe...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2020/8827038 |
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| author | Provvidenza M. Abruzzo Silvia Canaider Valeria Pizzuti Luca Pampanella Raffaella Casadei Federica Facchin Carlo Ventura |
| author_facet | Provvidenza M. Abruzzo Silvia Canaider Valeria Pizzuti Luca Pampanella Raffaella Casadei Federica Facchin Carlo Ventura |
| author_sort | Provvidenza M. Abruzzo |
| collection | DOAJ |
| description | Cellular senescence plays a very important role in organismal aging increasing with age and in age-related diseases (ARDs). This process involves physiological, structural, biochemical, and molecular changes of cells, leading to a characteristic trait referred to “senescence-associated secretory phenotype (SASP).” In particular, with aging, stem cells (SCs) in situ exhibit a diminished capacity of self-renewal and show a decline in their functionality. The identification of interventions able to prevent the accumulation of senescent SCs in the organism or to pretreat cultured multipotent mesenchymal stromal cells (MSCs) prior to employing them for cell therapy is a main purpose of medical research. Many approaches have been investigated and resulted effective to prevent or counteract SC senescence in humans, as well as other animal models. In this work, we have reviewed the chance of using a number of herb-derived products as novel tools in the treatment of cell senescence, highlighting the efficacy of these agents, often still far from being clearly understood. |
| format | Article |
| id | doaj-art-e75a705a8bce4d12ae571849db839c17 |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e75a705a8bce4d12ae571849db839c172025-08-20T02:21:10ZengWileyStem Cells International1687-966X1687-96782020-01-01202010.1155/2020/88270388827038Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell SenescenceProvvidenza M. Abruzzo0Silvia Canaider1Valeria Pizzuti2Luca Pampanella3Raffaella Casadei4Federica Facchin5Carlo Ventura6Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment for Life Quality Studies (QuVi), University of Bologna, Corso D’Augusto 237, 47921 Rimini, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Via Massarenti 9, 40138 Bologna, ItalyCellular senescence plays a very important role in organismal aging increasing with age and in age-related diseases (ARDs). This process involves physiological, structural, biochemical, and molecular changes of cells, leading to a characteristic trait referred to “senescence-associated secretory phenotype (SASP).” In particular, with aging, stem cells (SCs) in situ exhibit a diminished capacity of self-renewal and show a decline in their functionality. The identification of interventions able to prevent the accumulation of senescent SCs in the organism or to pretreat cultured multipotent mesenchymal stromal cells (MSCs) prior to employing them for cell therapy is a main purpose of medical research. Many approaches have been investigated and resulted effective to prevent or counteract SC senescence in humans, as well as other animal models. In this work, we have reviewed the chance of using a number of herb-derived products as novel tools in the treatment of cell senescence, highlighting the efficacy of these agents, often still far from being clearly understood.http://dx.doi.org/10.1155/2020/8827038 |
| spellingShingle | Provvidenza M. Abruzzo Silvia Canaider Valeria Pizzuti Luca Pampanella Raffaella Casadei Federica Facchin Carlo Ventura Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence Stem Cells International |
| title | Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence |
| title_full | Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence |
| title_fullStr | Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence |
| title_full_unstemmed | Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence |
| title_short | Herb-Derived Products: Natural Tools to Delay and Counteract Stem Cell Senescence |
| title_sort | herb derived products natural tools to delay and counteract stem cell senescence |
| url | http://dx.doi.org/10.1155/2020/8827038 |
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