The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study
Background: It is assumed that the severity of the multiple organ dysfunctions syndrome (MODS) in children who have experienced critical conditions in the neonatal period is a risk factor for the development of acute respiratory infections (ARI). Objective.The Aim was to study the relationship betwe...
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Union of pediatricians of Russia
2018-01-01
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| Series: | Педиатрическая фармакология |
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| Online Access: | https://www.pedpharma.ru/jour/article/view/1576 |
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| author | Elena N. Serebryakova Irina A. Belyaeva Dmitrii K. Volosnikov |
| author_facet | Elena N. Serebryakova Irina A. Belyaeva Dmitrii K. Volosnikov |
| author_sort | Elena N. Serebryakova |
| collection | DOAJ |
| description | Background: It is assumed that the severity of the multiple organ dysfunctions syndrome (MODS) in children who have experienced critical conditions in the neonatal period is a risk factor for the development of acute respiratory infections (ARI). Objective.The Aim was to study the relationship between the severities of organ dysfunctions in children who had undergone critical conditions in the neonatal period, with an ARI frequency at preschool age.Methods: The study included children with MODS, the severity of which was assessed on the NEOMOD scale (moderate dysfunction 4 points, severe 5 points). An infectious index (II) was calculated since the discharge from the hospital till the age of 7: the ratio of the number of cases ARI during the past year to the age of the child that year, and the proportion of often ill children (OIC) — the number of ARI 4, 6 and 5 cases per year at the age of 1, 1–3 and 4– 5 years respectively. Data on cases of ARI are obtained from the history of child development (form № 112/y).Results: The study included 198 children, 100 of them with severe manifestations of MODS and 98 with moderate manifestations of MODS. The groups were comparable by sex, age, social factors (age and level of education of parents), place of residence (city / village). II (median and 95% confidence interval) in children with severe and moderate manifestations of MODS under 1 year were 2 (2; 3) and 1.5 (1; 2) respectively (p=0.006); 1–2 years — 1.5 (1–2) and 1 (1– 1.5) (p=0.008); 2–3 years — 1 (0.7–1.2) and 0.7 (0.5–1) (p=0.006); 3–4 years old — 1,1 (0,8–1,3) and 0,8 (0,6–0,8) (р=0.003); 4–5 years — 0,6 (0.6–0,7) and 0,4 (0.4–0,5) (р=0.001); 5–6 years — 0.5 (0.3–0.5) and 0.3 (0.2–0.3) (p=0.001); 6–7 years — 0.3 (0.3–0.3) and 0.1 (0.1–0.3) (p=0.025). The OIC in the groups for the entire follow-up period was 60 (60%) and 42 (43%) respectively (p=0.011).Сonclusion: Severe manifestations of MODS in the neonatal period are associated with a higher susceptibility of children to ARI. |
| format | Article |
| id | doaj-art-e75a3d46014949ee970ee7c1213db8ee |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2018-01-01 |
| publisher | Union of pediatricians of Russia |
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| series | Педиатрическая фармакология |
| spelling | doaj-art-e75a3d46014949ee970ee7c1213db8ee2025-08-20T03:19:39ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892018-01-0114646947710.15690/pf.v14i6.18301539The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort StudyElena N. Serebryakova0Irina A. Belyaeva1Dmitrii K. Volosnikov2South Ural State Medical UniversityNational Medical Research Center for Children’s Health Russian National Research Medical University named after N.I. PirogovSouth Ural State Medical UniversityBackground: It is assumed that the severity of the multiple organ dysfunctions syndrome (MODS) in children who have experienced critical conditions in the neonatal period is a risk factor for the development of acute respiratory infections (ARI). Objective.The Aim was to study the relationship between the severities of organ dysfunctions in children who had undergone critical conditions in the neonatal period, with an ARI frequency at preschool age.Methods: The study included children with MODS, the severity of which was assessed on the NEOMOD scale (moderate dysfunction 4 points, severe 5 points). An infectious index (II) was calculated since the discharge from the hospital till the age of 7: the ratio of the number of cases ARI during the past year to the age of the child that year, and the proportion of often ill children (OIC) — the number of ARI 4, 6 and 5 cases per year at the age of 1, 1–3 and 4– 5 years respectively. Data on cases of ARI are obtained from the history of child development (form № 112/y).Results: The study included 198 children, 100 of them with severe manifestations of MODS and 98 with moderate manifestations of MODS. The groups were comparable by sex, age, social factors (age and level of education of parents), place of residence (city / village). II (median and 95% confidence interval) in children with severe and moderate manifestations of MODS under 1 year were 2 (2; 3) and 1.5 (1; 2) respectively (p=0.006); 1–2 years — 1.5 (1–2) and 1 (1– 1.5) (p=0.008); 2–3 years — 1 (0.7–1.2) and 0.7 (0.5–1) (p=0.006); 3–4 years old — 1,1 (0,8–1,3) and 0,8 (0,6–0,8) (р=0.003); 4–5 years — 0,6 (0.6–0,7) and 0,4 (0.4–0,5) (р=0.001); 5–6 years — 0.5 (0.3–0.5) and 0.3 (0.2–0.3) (p=0.001); 6–7 years — 0.3 (0.3–0.3) and 0.1 (0.1–0.3) (p=0.025). The OIC in the groups for the entire follow-up period was 60 (60%) and 42 (43%) respectively (p=0.011).Сonclusion: Severe manifestations of MODS in the neonatal period are associated with a higher susceptibility of children to ARI.https://www.pedpharma.ru/jour/article/view/1576newbornspreschool childrenmultiple organ dysfunctions syndromeacute respiratory diseasesriskprematurityantibiotic therapycatamnesis |
| spellingShingle | Elena N. Serebryakova Irina A. Belyaeva Dmitrii K. Volosnikov The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study Педиатрическая фармакология newborns preschool children multiple organ dysfunctions syndrome acute respiratory diseases risk prematurity antibiotic therapy catamnesis |
| title | The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study |
| title_full | The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study |
| title_fullStr | The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study |
| title_full_unstemmed | The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study |
| title_short | The Incidence of Acute Respiratory Infections in Children who Have Undergone Critical Conditions in the Neonatal Period, Depending on the Severity оf Organ Dysfunction. Retrospective Cohort Study |
| title_sort | incidence of acute respiratory infections in children who have undergone critical conditions in the neonatal period depending on the severity оf organ dysfunction retrospective cohort study |
| topic | newborns preschool children multiple organ dysfunctions syndrome acute respiratory diseases risk prematurity antibiotic therapy catamnesis |
| url | https://www.pedpharma.ru/jour/article/view/1576 |
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