Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers
Summary: Cancer is a heterogeneous disease driven by dysregulated cell death, which influences tumor progression and treatment responses. It is important to construct a systematic landscape that characterizes the dysregulation of regulated cell death (RCD) in tumor cells and accurately depicts the e...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225014622 |
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| author | Yunpeng Zhang Qi Ou Congxue Hu Chuo Peng Tengyue Li Xiaozhi Huang Kuan Yang Liyuan Li Xia Li Yingqi Xu |
| author_facet | Yunpeng Zhang Qi Ou Congxue Hu Chuo Peng Tengyue Li Xiaozhi Huang Kuan Yang Liyuan Li Xia Li Yingqi Xu |
| author_sort | Yunpeng Zhang |
| collection | DOAJ |
| description | Summary: Cancer is a heterogeneous disease driven by dysregulated cell death, which influences tumor progression and treatment responses. It is important to construct a systematic landscape that characterizes the dysregulation of regulated cell death (RCD) in tumor cells and accurately depicts the evolutionary relationships between different cell death types within these cells. Using single-cell analysis tools, we analyzed 477,766 tumor cells from 458 samples across 30 cancer types and identified 178 relationships between 15 RCD states and cancers. Pyroptosis and immunogenic cell death were found to be prevalent in most cancer types, especially skin, hematologic, digestive, urological, and lung cancers. We identified 37 significant interaction patterns, 22 transformation modules, and 153 driver genes linked to RCD evolution in 23 cancer types. Additionally, we developed “Secret,” a visual platform for RCD-related research. This study highlights the role of RCD in cancer progression and provides insights for targeted RCD-based therapies. |
| format | Article |
| id | doaj-art-e75702271cf24518902e9b97a46f5c3a |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-e75702271cf24518902e9b97a46f5c3a2025-08-20T03:45:10ZengElsevieriScience2589-00422025-08-0128811320110.1016/j.isci.2025.113201Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancersYunpeng Zhang0Qi Ou1Congxue Hu2Chuo Peng3Tengyue Li4Xiaozhi Huang5Kuan Yang6Liyuan Li7Xia Li8Yingqi Xu9College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China; Corresponding authorCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, ChinaCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China; Corresponding authorCollege of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China; Corresponding authorSummary: Cancer is a heterogeneous disease driven by dysregulated cell death, which influences tumor progression and treatment responses. It is important to construct a systematic landscape that characterizes the dysregulation of regulated cell death (RCD) in tumor cells and accurately depicts the evolutionary relationships between different cell death types within these cells. Using single-cell analysis tools, we analyzed 477,766 tumor cells from 458 samples across 30 cancer types and identified 178 relationships between 15 RCD states and cancers. Pyroptosis and immunogenic cell death were found to be prevalent in most cancer types, especially skin, hematologic, digestive, urological, and lung cancers. We identified 37 significant interaction patterns, 22 transformation modules, and 153 driver genes linked to RCD evolution in 23 cancer types. Additionally, we developed “Secret,” a visual platform for RCD-related research. This study highlights the role of RCD in cancer progression and provides insights for targeted RCD-based therapies.http://www.sciencedirect.com/science/article/pii/S2589004225014622cancer systems biology |
| spellingShingle | Yunpeng Zhang Qi Ou Congxue Hu Chuo Peng Tengyue Li Xiaozhi Huang Kuan Yang Liyuan Li Xia Li Yingqi Xu Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers iScience cancer systems biology |
| title | Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers |
| title_full | Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers |
| title_fullStr | Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers |
| title_full_unstemmed | Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers |
| title_short | Dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers |
| title_sort | dissecting regulated cell death states and transformation mechanisms in the evolutionary trajectory of 30 cancers |
| topic | cancer systems biology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225014622 |
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