Occurrence of extended spectrum beta-lactamase-producing enterobacteriaceae at Edward Francis Small Teaching Hospital, Banjul, The Gambia 2022: A hospital-based study
Introduction: Extended spectrum beta-lactamases producer enterobacteriaceae (ESBL_PE) are increasing in both hospital and community settings posing a major public health problem worldwide. In The Gambia, published data on the occurrence of ESBL-PE in local settings is limited. We determined the occu...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
African Field Epidemiology Network
2025-07-01
|
| Series: | Journal of Interventional Epidemiology and Public Health |
| Subjects: | |
| Online Access: | https://afenet-journal.org/occurrence-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-at-edward-francis-small-teaching-hospital-banjul-the-gambia-2022-a-hospital-based-study/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction: Extended spectrum beta-lactamases producer enterobacteriaceae (ESBL_PE) are increasing in both hospital and community settings posing a major public health problem worldwide. In The Gambia, published data on the occurrence of ESBL-PE in local settings is limited. We determined the occurrence of ESBL-PE from clinical samples at the main tertiary hospital, Edward Francis Small Teaching Hospital (EFSTH), The Gambia.
Methods: From December 2021 to August 2022, 173 banked clinical isolates were analysed using standard bacteriological methods at the EFSTH microbiology laboratory. Isolates identification was conducted using biochemical tests. Antibiotic susceptibility was conducted using the disk diffusion method according to Clinical and Laboratory Standard Institute (CLSI) guidelines. Phenotypic ESBL- PE was confirmed using double-disk synergy methods. Data on demographic characteristics, ward and sample type was collected from laboratory registers and request forms. Data was analysed descriptively using Epi info 7.5.
Results: A total of 173 single clinical isolates were analysed. ESBL-PE frequency was 35 (28.46%) among the 123 Enterobacteriaceae isolates identified. Majority of the ESBL PE isolates were from gynaecology ward 14(40%), followed by the surgical ward, 11 (31.43%). Escherichia coli was dominant 21 (60%) followed by Klebsiella pneumoniae 10 (28.57%). A high resistance rate was observed against Cephalosporins [(Ceftazidime 34 (97.14%), Cefotaxime 29(82.9%), Ceftriaxone 33 (94.29%)], Cotrimoxazole 33 (94.29%) and Gentamycin 32 (91.43%). A low resistance rate of ESBL-producers against Nitrofurantoin 9 (42.9) was observed. However, all the ESBL isolates were sensitive to Imipenem antibiotics. Multi-drug-resistant isolates were more prevalent among the ESBL_PE 33 (94.29%) than non-producers 2 (5.71%) (p = <0.0001)
Conclusion: Our study shows ESBL-producing Enterobacteriaceae from the banked clinical isolates, with Escherichia coli and Klebsiella pneumoniae as the predominant organisms. ESBL-producing organisms show a high resistance rate to cephalosporins. The hospital management should implement infection prevention and control measures within gynaecology and surgical wards – the most affected wards to prevent the spread of ESBL-PE. |
|---|---|
| ISSN: | 2664-2824 |