Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study

Causal relationship of familial hypercholesterolemia with risk of intestinal vascular disorders: A mendelian randomization study

Background: The causal relationship between the familial hypercholesterolemia (FH) and intestinal vascular diseases was unnoticed. This study aims to investigate the cause-and-effect relationship of FH with risk of intestinal vascular diseases in human. Methods: A Mendelian randomization (MR) analys...

Full description

Saved in:

Bibliographic Details
Main Authors:	Gang Wei, Cheng Zhang, Feng-Jie Shen, Hua-Qi Guo, Lin Liu
Format:	Article
Language:	English
Published:	Elsevier 2025-03-01
Series:	Metabolism Open
Subjects:	Familial hypercholesterolemia Intestinal vascular diseases ApoB PCSK9 CDKN2B-AS1
Online Access:	http://www.sciencedirect.com/science/article/pii/S2589936825000088
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

ApoB100 remodeling and stiffened cholesteryl ester core raise LDL aggregation in familial hypercholesterolemia patients
by: Maria Teresa La Chica Lhoëst, et al.
Published: (2025-01-01)

Optimal calorie restriction threshold: effect of FATmax exercise combined with different proportions of calorie restriction on hypercholesterolemia
by: Yuetong Wu, et al.
Published: (2025-01-01)

Familial Hypercholesterolemia: Genetics, Symptoms, Diagnosis and Treatment - A Literature Overview
by: Maciej Rutkiewicz, et al.
Published: (2025-02-01)

A novel mutation, Ile344Asn, in microsomal triglyceride transfer protein abolishes binding to protein disulfide isomerase
by: Swati Valmiki, et al.
Published: (2025-01-01)

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction
by: Simon Rauterberg, et al.
Published: (2025-01-01)

2024 Polish recommendations for the management of familial hypercholesterolemia in children and adolescents
by: Małgorzata Myśliwiec, et al.
Published: (2024-11-01)

Lipoprotein (a) levels in children with heterozygous familial hypercholesterolemia
by: Liliya F. Galimova, et al.
Published: (2024-12-01)

Case report of familial hypercholesterolemia with internal carotid neck swelling
by: Sudesh Kumar, et al.
Published: (2025-01-01)

Beyond identification of familial hypercholesterolemia: Improving downstream visits and treatments in a large health care system
by: Harin Lee, et al.
Published: (2025-03-01)

Exploring serum miR-33b as a novel diagnostic marker for hypercholesterolemia and obesity: insights from a pilot case-control study
by: Yaser Masoumi-Ardakani, et al.
Published: (2025-01-01)

Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice
by: Xue-Ying Zhang, et al.
Published: (2025-02-01)

Analysis of the low density lipoprotein receptor gene (<i>LDLR</i>) mutation spectrum in Russian familial hypercholesterolemia
by: V. B. Vasilyev, et al.
Published: (2022-06-01)

Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning
by: D. E. Ivanoshchuk, et al.
Published: (2023-09-01)

Liver transplantation for homozygous familial hypercholesterolemia: a retrospective analysis from Chinese experience
by: Hao-Su Zhan, et al.
Published: (2025-01-01)

Rheumatoid-like hand deformities and aortic valve disease in a 13-year-old girl with homozygous familial hypercholesterolemia: a case report
by: Anjuman Ara Rahman, et al.
Published: (2025-02-01)

The impact of Kersen leaves (Muntingia calabura L.) extract on Mus musculus with hypercholesterolemia
by: Sion Benu, et al.
Published: (2024-08-01)

Effect of onion oil on some haematological parameters in dogs with experimentally induced hypercholesterolemia
by: Ercan Keskin, et al.

The effect of the fenugreek hydrolyzed protein on lipid profile in patients with mild-to-moderate hypercholesterolemia: A confirmatory triple-blind randomized-controlled clinical trial
by: Mahdi Badiee Gavarti, et al.
Published: (2025-02-01)

Dyslipidemia Impacts Cardiometabolic Health and CVD Risk in a Relatively Young Otherwise Healthy Population
by: Jillian M. Lang, et al.
Published: (2025-01-01)

Potentially probiotic NPL 1334 strain of Enterococcus durans benefits rats with diet-induced hypercholesterolemia
by: Hannan Rashid, et al.
Published: (2025-01-01)

Efficacy and safety of PCSK9 inhibitors, potent statins, and their combinations for reducing low-density lipoprotein cholesterol in hyperlipidemia patients: a systematic network meta-analysis
by: Yuhua Jiang, et al.
Published: (2025-02-01)

Mutual mediation effects of homocysteine and PCSK9 on coronary lesion severity in patients with acute coronary syndrome: interplay with inflammatory and lipid markers
by: Ping Jin, et al.
Published: (2025-01-01)

Retrospective investigation of non-traumatic small intestine perforations: Our single center 7-year clinical experiences
by: Sebnem Cimen, et al.
Published: (2024-04-01)

A strategy to increase identification of patients with Familial Hypercholesterolemia: Application of the Simon Broome lipid criteria in a large-scale retrospective analysis
by: James K. Fleming, et al.
Published: (2025-03-01)

A new prognostic model based on serum apolipoprotein AI in patients with HBV-ACLF and acutely decompensated liver cirrhosis
by: Ruidong Mo, et al.
Published: (2025-02-01)

New epigenome players in the regulation of PCSK9-H3K4me3 and H3K9ac alterations by statin in hypercholesterolemia
by: Sushmitha Duddu, et al.
Published: (2025-01-01)

Trend of the lipid profile in a cohort with severe hypercholesterolemia in Osona county (Barcelona, Spain), between 2009 and 2021
by: Jordi Prat-Quinzaños, et al.
Published: (2025-01-01)

Smoking Induces the Circulating Levels of Matrix Metalloproteinase-9 and Its Association with Cardiovascular Risk in Young Smokers
by: Dinesh NATH, et al.
Published: (2022-12-01)

Association of Insomnia, Lipid Profile, and Lipid-Lowering Medications: A Narrative Review
by: Fang Jia, et al.
Published: (2025-01-01)

Effects of dietary Bacillus pumilus on the growth, intestinal health, lipid metabolism, and mTOR signaling pathway of juvenile coho salmon (Oncorhynchus kisutch)
by: Mengjie Guo, et al.
Published: (2025-01-01)

The relationship between oxLDL, sLOX-1, PCSK9 and carotid intima-media thickness in patients with prediabetes and type 2 diabetes
by: Zeki Dogan, et al.
Published: (2025-02-01)

Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma
by: Laura Scalambra, et al.
Published: (2025-01-01)

Harnessing genomic and bioinformatic data to broaden understanding of leukaemia across continents
by: Gumelar Gugun, et al.
Published: (2024-01-01)

Lactobacillus fermentum B153 from human colostrum modulates intestinal immunity and gut microbiota in obese mice model
by: Juqing Huang, et al.
Published: (2025-02-01)

Regulation of nuclear factor-κB in intestinal epithelial cells in a cell model of inflammation
by: Fadia R. Homaidan, et al.
Published: (2003-01-01)

SELECTION FOR BEHAVIOR AND CORRELATION WITH THE MACROGLOBULINE AND LYPOPROTEINE SYSTEMS IN THE AMERICAN MINK (NEOVISON VISON)
by: V. I. Ermolaev, et al.
Published: (2015-01-01)

N-acetylcysteine increased the growth performance of Leuciscus waleckii by improving mitochondrial function, enhancing antioxidant and anti-inflammatory, and inhibiting apoptosis in the hepatopancreas and intestine
by: Deng Lai Li, et al.
Published: (2025-03-01)

Identification of CDKN3 overexpression as a marker of poor prognosis and potential therapeutic target in low-grade glioma
by: Hongbing Cheng, et al.
Published: (2025-01-01)

PCSK9 affects vascular senescence through the SIRT1 pathway
by: Yuqin Wang, et al.
Published: (2025-03-01)

High-selenium exposure is associated with modulation of serum lipid metabolism
by: Yong Tan, et al.
Published: (2025-01-01)