Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Objective: Schizophrenia which is a chronic disabling burdensome psychotic disorder has been treated with different antipsychotic medications. Some studies have reported a possible correlation between deficiency in minerals, nutrients and vitamins — mainly group B vitamins — and the development of...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2024-12-01
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| Series: | Iranian Journal of Psychiatry |
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| Online Access: | https://ijps.tums.ac.ir/index.php/ijps/article/view/3798 |
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| _version_ | 1841558606324957184 |
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| author | Somayeh Agmashe Gita Sadighi Narges Radman Robabeh Mazinani |
| author_facet | Somayeh Agmashe Gita Sadighi Narges Radman Robabeh Mazinani |
| author_sort | Somayeh Agmashe |
| collection | DOAJ |
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Objective: Schizophrenia which is a chronic disabling burdensome psychotic disorder has been treated with different antipsychotic medications. Some studies have reported a possible correlation between deficiency in minerals, nutrients and vitamins — mainly group B vitamins — and the development of schizophrenia. In the present study, we aimed to examine the effect of the B vitamin group as an adjuvant treatment to antipsychotics in individuals with chronic schizophrenia.
Method: In a randomized, double-blind clinical trial study, involving two groups of 25 patients with chronic schizophrenia, we compared the effects of a 12-week adjuvant treatment with a combination of B vitamins — B1 (15mg), B2 (15mg), B6 (10mg), B12 (10µg) and nicotinamide (50 mg) — with a placebo. The impact on negative, positive and cognitive symptoms of schizophrenia was assessed for both groups before the intervention (T0) and at 4, 8 and 12 weeks after the intervention (T1, T2, and T3, respectively).
Results: Following the treatment, negative symptoms scores decreased in the treatment group at 12 weeks following the beginning of the treatment (F (4, 45) = 464.7, P < 0.0001). Although a trend toward improvement in positive symptoms and cognitive scores was seen, these changes were not significant.
Conclusion: Our results suggest that selecting the group B vitamins as an adjuvant treatment to the antipsychotics may have beneficial effects on improving negative symptoms of patients with chronic schizophrenia.
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| format | Article |
| id | doaj-art-e752c21f57fe4326be3498ece79906e5 |
| institution | Kabale University |
| issn | 1735-4587 2008-2215 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Psychiatry |
| spelling | doaj-art-e752c21f57fe4326be3498ece79906e52025-01-06T08:39:43ZengTehran University of Medical SciencesIranian Journal of Psychiatry1735-45872008-22152024-12-0120110.18502/ijps.v20i1.17396Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical TrialSomayeh Agmashe0Gita Sadighi1Narges Radman2Robabeh Mazinani3Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.Department of Psychiatry, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.Psychosis Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Objective: Schizophrenia which is a chronic disabling burdensome psychotic disorder has been treated with different antipsychotic medications. Some studies have reported a possible correlation between deficiency in minerals, nutrients and vitamins — mainly group B vitamins — and the development of schizophrenia. In the present study, we aimed to examine the effect of the B vitamin group as an adjuvant treatment to antipsychotics in individuals with chronic schizophrenia. Method: In a randomized, double-blind clinical trial study, involving two groups of 25 patients with chronic schizophrenia, we compared the effects of a 12-week adjuvant treatment with a combination of B vitamins — B1 (15mg), B2 (15mg), B6 (10mg), B12 (10µg) and nicotinamide (50 mg) — with a placebo. The impact on negative, positive and cognitive symptoms of schizophrenia was assessed for both groups before the intervention (T0) and at 4, 8 and 12 weeks after the intervention (T1, T2, and T3, respectively). Results: Following the treatment, negative symptoms scores decreased in the treatment group at 12 weeks following the beginning of the treatment (F (4, 45) = 464.7, P < 0.0001). Although a trend toward improvement in positive symptoms and cognitive scores was seen, these changes were not significant. Conclusion: Our results suggest that selecting the group B vitamins as an adjuvant treatment to the antipsychotics may have beneficial effects on improving negative symptoms of patients with chronic schizophrenia. https://ijps.tums.ac.ir/index.php/ijps/article/view/3798B VitaminsClinical TrialCognitionPsychotic DisorderSchizophrenia |
| spellingShingle | Somayeh Agmashe Gita Sadighi Narges Radman Robabeh Mazinani Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Iranian Journal of Psychiatry B Vitamins Clinical Trial Cognition Psychotic Disorder Schizophrenia |
| title | Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full | Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_fullStr | Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_full_unstemmed | Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_short | Effects of B Vitamins on Symptoms and Cognitive Functions in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial |
| title_sort | effects of b vitamins on symptoms and cognitive functions in schizophrenia a randomized double blind placebo controlled clinical trial |
| topic | B Vitamins Clinical Trial Cognition Psychotic Disorder Schizophrenia |
| url | https://ijps.tums.ac.ir/index.php/ijps/article/view/3798 |
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