Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model
Over the past 40 years, the pig-to-nonhuman primate organ transplantation model has enabled progress in xenotransplantation to be made to the point that we are now carrying out initial US FDA-approved clinical experiments on “compassionate” grounds. More recently, the pig-to-human brain-dead deceden...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-08-01
|
| Series: | Transplant International |
| Subjects: | |
| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14452/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849391875401711616 |
|---|---|
| author | D. K. C. Cooper L. Mou J. D. Cleveland J. H. Simmons D. C. Cleveland |
| author_facet | D. K. C. Cooper L. Mou J. D. Cleveland J. H. Simmons D. C. Cleveland |
| author_sort | D. K. C. Cooper |
| collection | DOAJ |
| description | Over the past 40 years, the pig-to-nonhuman primate organ transplantation model has enabled progress in xenotransplantation to be made to the point that we are now carrying out initial US FDA-approved clinical experiments on “compassionate” grounds. More recently, the pig-to-human brain-dead decedent model was introduced with claims that this might replace (or at least augment) the pig-to-NHP model. There are, however, several limitations of the decedent model, most notably the very limited period during which the subject may remain sufficiently metabolically and hemodynamically stable to allow meaningful monitoring of the fate of a pig organ graft. It will be exceedingly difficult to provide the regulatory authorities with data from experiments in which truly prolonged graft function has been monitored, whereas this is already being achieved in the pig-to-NHP model. In view of the complications related to the effects of brain death, the data obtained from xenotransplantation experiments in decedents may provide confusing results. There is a real risk that this may influence the regulatory authorities to become overly cautious in approving formal clinical trials of pig organ xenotransplantation to be initiated. We conclude that experiments in human decedents will be unable to replace studies in pig-to-NHP models. |
| format | Article |
| id | doaj-art-e75284ade21e4fac841021adb2c12ffb |
| institution | Kabale University |
| issn | 1432-2277 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj-art-e75284ade21e4fac841021adb2c12ffb2025-08-20T03:40:54ZengFrontiers Media S.A.Transplant International1432-22772025-08-013810.3389/ti.2025.1445214452Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent ModelD. K. C. Cooper0L. Mou1J. D. Cleveland2J. H. Simmons3D. C. Cleveland4Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, MA, United StatesShenzhen Xenotransplantation Medical Engineering Research and Development Center, Shenzhen Institute of Translational Medicine, Health Science Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen, ChinaChildren’s Hospital of Los Angeles, University of Southern California, Los Angeles, CA, United StatesMichale E. Keeling Center for Comparative Medicine and Research, University of Texas MD Anderson Cancer Center, Bastrop, TX, United StatesChildren’s Hospital of Los Angeles, University of Southern California, Los Angeles, CA, United StatesOver the past 40 years, the pig-to-nonhuman primate organ transplantation model has enabled progress in xenotransplantation to be made to the point that we are now carrying out initial US FDA-approved clinical experiments on “compassionate” grounds. More recently, the pig-to-human brain-dead decedent model was introduced with claims that this might replace (or at least augment) the pig-to-NHP model. There are, however, several limitations of the decedent model, most notably the very limited period during which the subject may remain sufficiently metabolically and hemodynamically stable to allow meaningful monitoring of the fate of a pig organ graft. It will be exceedingly difficult to provide the regulatory authorities with data from experiments in which truly prolonged graft function has been monitored, whereas this is already being achieved in the pig-to-NHP model. In view of the complications related to the effects of brain death, the data obtained from xenotransplantation experiments in decedents may provide confusing results. There is a real risk that this may influence the regulatory authorities to become overly cautious in approving formal clinical trials of pig organ xenotransplantation to be initiated. We conclude that experiments in human decedents will be unable to replace studies in pig-to-NHP models.https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14452/fullkidneyxenotransplantationbrain deathdecedentnonhuman primate |
| spellingShingle | D. K. C. Cooper L. Mou J. D. Cleveland J. H. Simmons D. C. Cleveland Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model Transplant International kidney xenotransplantation brain death decedent nonhuman primate |
| title | Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model |
| title_full | Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model |
| title_fullStr | Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model |
| title_full_unstemmed | Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model |
| title_short | Xenotransplantation Research -the Nonhuman Primate Model Is Preferable to the Human Decedent Model |
| title_sort | xenotransplantation research the nonhuman primate model is preferable to the human decedent model |
| topic | kidney xenotransplantation brain death decedent nonhuman primate |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2025.14452/full |
| work_keys_str_mv | AT dkccooper xenotransplantationresearchthenonhumanprimatemodelispreferabletothehumandecedentmodel AT lmou xenotransplantationresearchthenonhumanprimatemodelispreferabletothehumandecedentmodel AT jdcleveland xenotransplantationresearchthenonhumanprimatemodelispreferabletothehumandecedentmodel AT jhsimmons xenotransplantationresearchthenonhumanprimatemodelispreferabletothehumandecedentmodel AT dccleveland xenotransplantationresearchthenonhumanprimatemodelispreferabletothehumandecedentmodel |