A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran
Introduction: Multidrug-resistant (MDR) bacteria like Proteus species have led to more prolonged hospitalizations, fewer care choices, higher treatment costs, and even death. The present study aims to evaluate the prevalence of MDR Proteus species in clinical samples and to suggest the best therape...
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The Journal of Infection in Developing Countries
2024-12-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/17637 |
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| author | Mahnaz Shafaei Fallah Hadi Razavi Nikoo Aylar Jamali Alireza Mohebbi Ezzat Allah Ghaemi |
| author_facet | Mahnaz Shafaei Fallah Hadi Razavi Nikoo Aylar Jamali Alireza Mohebbi Ezzat Allah Ghaemi |
| author_sort | Mahnaz Shafaei Fallah |
| collection | DOAJ |
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Introduction: Multidrug-resistant (MDR) bacteria like Proteus species have led to more prolonged hospitalizations, fewer care choices, higher treatment costs, and even death. The present study aims to evaluate the prevalence of MDR Proteus species in clinical samples and to suggest the best therapeutic options for the MDR Proteus species.
Methodology: Clinical samples were collected randomly from five hospitals in Golestan Province, Iran, from February 2017 to July 2019. Disk diffusion on Mueller–Hinton agar plates were used to perform antibiotic susceptibility testing (ASTs). By using a double-disc synergy test (DDST), isolates resistant to one of the third-generation cephalosporins were examined for phenotypic extended-spectrum β-lactamase (ESBL) development. A combined double disk synergy test (CDDST) was used to identify MBL-producing isolates.
Results: 61 Proteus isolates, including P. Mirabilis 44/61 (77.04%), P. vulgaris 7/61 (11.47%), P. hauseri 5/61 (8.19%), and P. penneri 2/61 (3.27%) were collected. Most of the isolates were obtained from urine samples. P. hauseri isolates were more frequent in females. Resistance to tetracycline and nitrofurantoin antibiotics was observed in most Proteus isolates. P. penneri isolates were all resistant to antibiotics. ESBL production was observed in five ceftazidime-resistant isolates (p < 0.05).
Conclusions: Cefepime and imipenem were found to have the lowest occurrence of antibiotic resistance among Proteus species, confirming that cefepime and imipenem can be used to treat Proteus infections.
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| format | Article |
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| institution | Kabale University |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | The Journal of Infection in Developing Countries |
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| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-e74c3e6bcdc0487d856cb817b193a57e2025-08-20T03:52:42ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-12-01181210.3855/jidc.17637A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern IranMahnaz Shafaei Fallah0Hadi Razavi Nikoo1Aylar Jamali2Alireza Mohebbi3Ezzat Allah Ghaemi4Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, IranDepartment of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, IranDepartment of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, IranDepartment of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, IranLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran Introduction: Multidrug-resistant (MDR) bacteria like Proteus species have led to more prolonged hospitalizations, fewer care choices, higher treatment costs, and even death. The present study aims to evaluate the prevalence of MDR Proteus species in clinical samples and to suggest the best therapeutic options for the MDR Proteus species. Methodology: Clinical samples were collected randomly from five hospitals in Golestan Province, Iran, from February 2017 to July 2019. Disk diffusion on Mueller–Hinton agar plates were used to perform antibiotic susceptibility testing (ASTs). By using a double-disc synergy test (DDST), isolates resistant to one of the third-generation cephalosporins were examined for phenotypic extended-spectrum β-lactamase (ESBL) development. A combined double disk synergy test (CDDST) was used to identify MBL-producing isolates. Results: 61 Proteus isolates, including P. Mirabilis 44/61 (77.04%), P. vulgaris 7/61 (11.47%), P. hauseri 5/61 (8.19%), and P. penneri 2/61 (3.27%) were collected. Most of the isolates were obtained from urine samples. P. hauseri isolates were more frequent in females. Resistance to tetracycline and nitrofurantoin antibiotics was observed in most Proteus isolates. P. penneri isolates were all resistant to antibiotics. ESBL production was observed in five ceftazidime-resistant isolates (p < 0.05). Conclusions: Cefepime and imipenem were found to have the lowest occurrence of antibiotic resistance among Proteus species, confirming that cefepime and imipenem can be used to treat Proteus infections. https://jidc.org/index.php/journal/article/view/17637Proteusextended-spectrum β-lactamasemultidrug resistanceantimicrobial resistance |
| spellingShingle | Mahnaz Shafaei Fallah Hadi Razavi Nikoo Aylar Jamali Alireza Mohebbi Ezzat Allah Ghaemi A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran Journal of Infection in Developing Countries Proteus extended-spectrum β-lactamase multidrug resistance antimicrobial resistance |
| title | A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran |
| title_full | A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran |
| title_fullStr | A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran |
| title_full_unstemmed | A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran |
| title_short | A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran |
| title_sort | cross sectional study on the prevalence of multidrug resistant clinical isolates of proteus species in northern iran |
| topic | Proteus extended-spectrum β-lactamase multidrug resistance antimicrobial resistance |
| url | https://jidc.org/index.php/journal/article/view/17637 |
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