Clinical perspectives on post-cholecystectomy syndrome: a narrative review
Introduction Post-cholecystectomy syndrome (PCS) is a complex condition characterized by persistent or new symptoms following gallbladder removal, affecting up to 47% of patients. Despite being recognized since 1947, there is still no consensus on its etiology, diagnosis, and treatment.Areas covered...
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| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2496408 |
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| author | Changjin Nam Jun Suh Lee Ji Su Kim Tae Yoon Lee Young Chul Yoon |
| author_facet | Changjin Nam Jun Suh Lee Ji Su Kim Tae Yoon Lee Young Chul Yoon |
| author_sort | Changjin Nam |
| collection | DOAJ |
| description | Introduction Post-cholecystectomy syndrome (PCS) is a complex condition characterized by persistent or new symptoms following gallbladder removal, affecting up to 47% of patients. Despite being recognized since 1947, there is still no consensus on its etiology, diagnosis, and treatment.Areas covered This narrative review explores the multifactorial etiology of PCS, including biliary and extra-biliary factors, and its varied clinical manifestations. A systematic literature search was conducted using keywords like ‘etiology’, ‘clinical manifestations’, ‘diagnostic challenges’, and ‘management strategies’. The review covers traditional diagnostic methods, recent insights into pathophysiology, and current management approaches, such as dietary modifications, pharmacological treatments, and endoscopic interventions, with a focus on patient selection.Expert opinion PCS presents significant clinical challenges due to its diverse presentations and lack of standardized diagnostic and therapeutic protocols. Effective management starts with careful patient selection before cholecystectomy to prevent unnecessary surgeries and reduce postoperative complications. Future research should aim to refine diagnostic criteria and develop predictive models for identifying at-risk patients. Personalized management strategies incorporating genetic, biological, and clinical factors are essential for improving outcomes. An integrated, patient-centered approach is crucial for addressing PCS complexities and enhancing the quality of life for affected patients. |
| format | Article |
| id | doaj-art-e74753bb6bc643848daec5b92248f5e6 |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-e74753bb6bc643848daec5b92248f5e62025-08-20T02:19:47ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2496408Clinical perspectives on post-cholecystectomy syndrome: a narrative reviewChangjin Nam0Jun Suh Lee1Ji Su Kim2Tae Yoon Lee3Young Chul Yoon4Kyungpook National University Medical College, Daegu, Republic of KoreaDepartment of Surgery, Bucheon Sejong Hospital, Bucheon, Republic of KoreaDepartment of Surgery, Incheon St. Mary’s Hospital, Incheon, Republic of KoreaDepartment of Surgery, Incheon St. Mary’s Hospital, Incheon, Republic of KoreaDepartment of Surgery, Incheon St. Mary’s Hospital, Incheon, Republic of KoreaIntroduction Post-cholecystectomy syndrome (PCS) is a complex condition characterized by persistent or new symptoms following gallbladder removal, affecting up to 47% of patients. Despite being recognized since 1947, there is still no consensus on its etiology, diagnosis, and treatment.Areas covered This narrative review explores the multifactorial etiology of PCS, including biliary and extra-biliary factors, and its varied clinical manifestations. A systematic literature search was conducted using keywords like ‘etiology’, ‘clinical manifestations’, ‘diagnostic challenges’, and ‘management strategies’. The review covers traditional diagnostic methods, recent insights into pathophysiology, and current management approaches, such as dietary modifications, pharmacological treatments, and endoscopic interventions, with a focus on patient selection.Expert opinion PCS presents significant clinical challenges due to its diverse presentations and lack of standardized diagnostic and therapeutic protocols. Effective management starts with careful patient selection before cholecystectomy to prevent unnecessary surgeries and reduce postoperative complications. Future research should aim to refine diagnostic criteria and develop predictive models for identifying at-risk patients. Personalized management strategies incorporating genetic, biological, and clinical factors are essential for improving outcomes. An integrated, patient-centered approach is crucial for addressing PCS complexities and enhancing the quality of life for affected patients.https://www.tandfonline.com/doi/10.1080/07853890.2025.2496408Cholecystectomydiagnostic criteriagut microbiota alterationssphincter of Oddi dysfunctiontreatment outcomes |
| spellingShingle | Changjin Nam Jun Suh Lee Ji Su Kim Tae Yoon Lee Young Chul Yoon Clinical perspectives on post-cholecystectomy syndrome: a narrative review Annals of Medicine Cholecystectomy diagnostic criteria gut microbiota alterations sphincter of Oddi dysfunction treatment outcomes |
| title | Clinical perspectives on post-cholecystectomy syndrome: a narrative review |
| title_full | Clinical perspectives on post-cholecystectomy syndrome: a narrative review |
| title_fullStr | Clinical perspectives on post-cholecystectomy syndrome: a narrative review |
| title_full_unstemmed | Clinical perspectives on post-cholecystectomy syndrome: a narrative review |
| title_short | Clinical perspectives on post-cholecystectomy syndrome: a narrative review |
| title_sort | clinical perspectives on post cholecystectomy syndrome a narrative review |
| topic | Cholecystectomy diagnostic criteria gut microbiota alterations sphincter of Oddi dysfunction treatment outcomes |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2496408 |
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