Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk
Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%–70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pre...
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| Format: | Article |
| Language: | English |
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Mary Ann Liebert
2024-04-01
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| Series: | Women's Health Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/whr.2023.0120 |
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| author | Alexandra Bonmatí-Santané Roberto Céspedes López Jehimy Jean Alvarez Saltos Jordi Calabia Martínez Cristina Noboa Paez Jordi Piedra Sánchez Natalia Visa Figueredo Anna Maroto González |
| author_facet | Alexandra Bonmatí-Santané Roberto Céspedes López Jehimy Jean Alvarez Saltos Jordi Calabia Martínez Cristina Noboa Paez Jordi Piedra Sánchez Natalia Visa Figueredo Anna Maroto González |
| author_sort | Alexandra Bonmatí-Santané |
| collection | DOAJ |
| description | Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%–70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis. |
| format | Article |
| id | doaj-art-e7447f944fb3416e834f3f60f4b65181 |
| institution | DOAJ |
| issn | 2688-4844 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Women's Health Reports |
| spelling | doaj-art-e7447f944fb3416e834f3f60f4b651812025-08-20T03:09:58ZengMary Ann LiebertWomen's Health Reports2688-48442024-04-015131932310.1089/whr.2023.0120Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1PkAlexandra Bonmatí-Santané0Roberto Céspedes López1Jehimy Jean Alvarez Saltos2Jordi Calabia Martínez3Cristina Noboa Paez4Jordi Piedra Sánchez5Natalia Visa Figueredo6Anna Maroto González7Gynecology and Obstetrics Service, Girona, Spain.Department of Hematology, Banc de Sang i Teixits, Girona, Spain.Nephrorolgy Service; Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain.Nephrorolgy Service; Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain.Nephrorolgy Service; Hospital Universitari de Girona Doctor Josep Trueta, Girona, Spain.Department of Hematology, Banc de Sang i Teixits, Girona, Spain.Gynecology and Obstetrics Service, Girona, Spain.Gynecology and Obstetrics Service, Girona, Spain.Pregnant women with p phenotype, who lack antigens P, P1, and Pk, spontaneously form anti-PP1Pk antibodies whose primary target is the placenta. The risk of miscarriage in these women is 50%–70% and reaches 87% in the second trimester. The therapies aim to reduce the titer of antibodies early in pregnancy. They also have risk of hemolytic transfusion reaction, with very few compatible red blood cell donors in the world. In this study, we present a case of successful pregnancy managed with autologous blood donations and plasmapheresis.https://www.liebertpub.com/doi/10.1089/whr.2023.0120plasmapheresisanti-PP1Pkautologous blood donationmiscarriagep phenotype |
| spellingShingle | Alexandra Bonmatí-Santané Roberto Céspedes López Jehimy Jean Alvarez Saltos Jordi Calabia Martínez Cristina Noboa Paez Jordi Piedra Sánchez Natalia Visa Figueredo Anna Maroto González Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk Women's Health Reports plasmapheresis anti-PP1Pk autologous blood donation miscarriage p phenotype |
| title | Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk |
| title_full | Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk |
| title_fullStr | Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk |
| title_full_unstemmed | Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk |
| title_short | Managing a Pregnancy in the Presence of the Rare Blood Group Antibody PP1Pk |
| title_sort | managing a pregnancy in the presence of the rare blood group antibody pp1pk |
| topic | plasmapheresis anti-PP1Pk autologous blood donation miscarriage p phenotype |
| url | https://www.liebertpub.com/doi/10.1089/whr.2023.0120 |
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