Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival
The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum that respond to shifts in temperature by converting between hyphae (22–25°C) and yeast (37°C). This morphologic switch, known as the phase transition, defines the biology and lifestyle of these fungi. The conversi...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/8491383 |
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| author | Gregory M. Gauthier |
| author_facet | Gregory M. Gauthier |
| author_sort | Gregory M. Gauthier |
| collection | DOAJ |
| description | The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum that respond to shifts in temperature by converting between hyphae (22–25°C) and yeast (37°C). This morphologic switch, known as the phase transition, defines the biology and lifestyle of these fungi. The conversion to yeast within healthy and immunocompromised mammalian hosts is essential for virulence. In the yeast phase, the thermally dimorphic fungi upregulate genes involved with subverting host immune defenses. This review highlights the molecular mechanisms governing the phase transition and recent advances in how the phase transition promotes infection. |
| format | Article |
| id | doaj-art-e74366d379854e9d8b004b81479f3155 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
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| series | Mediators of Inflammation |
| spelling | doaj-art-e74366d379854e9d8b004b81479f31552025-02-03T05:59:57ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/84913838491383Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo SurvivalGregory M. Gauthier0Department of Medicine, Division of Infectious Diseases, University of Wisconsin School of Medicine & Public Health, Madison, WI, USAThe thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum that respond to shifts in temperature by converting between hyphae (22–25°C) and yeast (37°C). This morphologic switch, known as the phase transition, defines the biology and lifestyle of these fungi. The conversion to yeast within healthy and immunocompromised mammalian hosts is essential for virulence. In the yeast phase, the thermally dimorphic fungi upregulate genes involved with subverting host immune defenses. This review highlights the molecular mechanisms governing the phase transition and recent advances in how the phase transition promotes infection.http://dx.doi.org/10.1155/2017/8491383 |
| spellingShingle | Gregory M. Gauthier Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival Mediators of Inflammation |
| title | Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival |
| title_full | Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival |
| title_fullStr | Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival |
| title_full_unstemmed | Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival |
| title_short | Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival |
| title_sort | fungal dimorphism and virulence molecular mechanisms for temperature adaptation immune evasion and in vivo survival |
| url | http://dx.doi.org/10.1155/2017/8491383 |
| work_keys_str_mv | AT gregorymgauthier fungaldimorphismandvirulencemolecularmechanismsfortemperatureadaptationimmuneevasionandinvivosurvival |