Organoids in cancer therapies: a comprehensive review
Organoid technology has significantly advanced biomedical research, offering deep insights into tumor biology and therapeutic efficacy. While existing publications have covered organoid applications, this review uniquely stresses their transformative role in cancer research. We highlight their impor...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1607488/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849389783963402240 |
|---|---|
| author | Jiang Xin-Yi Jiang Xin-Yi Wang Yan-Ran Wang Yan-Ran Di Pin-Ru Di Pin-Ru Qian Shi-Yi Qian Shi-Yi Jiang Hai-Tao Jiang Hai-Tao |
| author_facet | Jiang Xin-Yi Jiang Xin-Yi Wang Yan-Ran Wang Yan-Ran Di Pin-Ru Di Pin-Ru Qian Shi-Yi Qian Shi-Yi Jiang Hai-Tao Jiang Hai-Tao |
| author_sort | Jiang Xin-Yi |
| collection | DOAJ |
| description | Organoid technology has significantly advanced biomedical research, offering deep insights into tumor biology and therapeutic efficacy. While existing publications have covered organoid applications, this review uniquely stresses their transformative role in cancer research. We highlight their importance in studying intratumoral heterogeneity and microenvironment interactions. Our analysis addresses knowledge gaps by detailing how organoids function as models in cancer initiation, drug screening, target identification, and sensitivity assessment. We also explore their applications in personalized medicine, such as developing patient-derived models for treatment prediction and immune therapy evaluation. This review discusses the latest progress in using organoids for cancer treatment, like predicting patient responses to precision medicine. However, challenges remain, including maintaining genetic stability and mimicking in vivo conditions. By addressing these limitations, this review provides a novel perspective on how organoid technology may overcome current barriers and drive innovation in cancer therapy. Our analysis suggests that advancements in organoid systems could enhance personalized treatment strategies and improve oncology patient outcomes. |
| format | Article |
| id | doaj-art-e741a91770f9427d9c63fcdfeaf81f37 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-e741a91770f9427d9c63fcdfeaf81f372025-08-20T03:41:51ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-07-011310.3389/fbioe.2025.16074881607488Organoids in cancer therapies: a comprehensive reviewJiang Xin-Yi0Jiang Xin-Yi1Wang Yan-Ran2Wang Yan-Ran3Di Pin-Ru4Di Pin-Ru5Qian Shi-Yi6Qian Shi-Yi7Jiang Hai-Tao8Jiang Hai-Tao9Department of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, ChinaSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, ChinaSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, ChinaSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, ChinaSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaDepartment of General Surgery, Ningbo No. 2 Hospital, Ningbo, Zhejiang, ChinaSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang, ChinaOrganoid technology has significantly advanced biomedical research, offering deep insights into tumor biology and therapeutic efficacy. While existing publications have covered organoid applications, this review uniquely stresses their transformative role in cancer research. We highlight their importance in studying intratumoral heterogeneity and microenvironment interactions. Our analysis addresses knowledge gaps by detailing how organoids function as models in cancer initiation, drug screening, target identification, and sensitivity assessment. We also explore their applications in personalized medicine, such as developing patient-derived models for treatment prediction and immune therapy evaluation. This review discusses the latest progress in using organoids for cancer treatment, like predicting patient responses to precision medicine. However, challenges remain, including maintaining genetic stability and mimicking in vivo conditions. By addressing these limitations, this review provides a novel perspective on how organoid technology may overcome current barriers and drive innovation in cancer therapy. Our analysis suggests that advancements in organoid systems could enhance personalized treatment strategies and improve oncology patient outcomes.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1607488/fullorganoidscancer therapydisease modelingdrug screeningpersonalized medicine |
| spellingShingle | Jiang Xin-Yi Jiang Xin-Yi Wang Yan-Ran Wang Yan-Ran Di Pin-Ru Di Pin-Ru Qian Shi-Yi Qian Shi-Yi Jiang Hai-Tao Jiang Hai-Tao Organoids in cancer therapies: a comprehensive review Frontiers in Bioengineering and Biotechnology organoids cancer therapy disease modeling drug screening personalized medicine |
| title | Organoids in cancer therapies: a comprehensive review |
| title_full | Organoids in cancer therapies: a comprehensive review |
| title_fullStr | Organoids in cancer therapies: a comprehensive review |
| title_full_unstemmed | Organoids in cancer therapies: a comprehensive review |
| title_short | Organoids in cancer therapies: a comprehensive review |
| title_sort | organoids in cancer therapies a comprehensive review |
| topic | organoids cancer therapy disease modeling drug screening personalized medicine |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1607488/full |
| work_keys_str_mv | AT jiangxinyi organoidsincancertherapiesacomprehensivereview AT jiangxinyi organoidsincancertherapiesacomprehensivereview AT wangyanran organoidsincancertherapiesacomprehensivereview AT wangyanran organoidsincancertherapiesacomprehensivereview AT dipinru organoidsincancertherapiesacomprehensivereview AT dipinru organoidsincancertherapiesacomprehensivereview AT qianshiyi organoidsincancertherapiesacomprehensivereview AT qianshiyi organoidsincancertherapiesacomprehensivereview AT jianghaitao organoidsincancertherapiesacomprehensivereview AT jianghaitao organoidsincancertherapiesacomprehensivereview |